FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2032181723> ?p ?o ?g. }

• W2032181723 endingPage "1297" @default.
• W2032181723 startingPage "1287" @default.
• W2032181723 abstract "Abstract In congenital mitochondrial DNA (mtDNA) disorders, a mixture of normal and mutated mtDNA (termed heteroplasmy) exists at varying levels in different tissues, which determines the severity and phenotypic expression of disease. Pearson marrow pancreas syndrome (PS) is a congenital bone marrow failure disorder caused by heteroplasmic deletions in mtDNA. The cause of the hematopoietic failure in PS is unknown, and adequate cellular and animal models are lacking. Induced pluripotent stem (iPS) cells are particularly amenable for studying mtDNA disorders, as cytoplasmic genetic material is retained during direct reprogramming. Here, we derive and characterize iPS cells from a patient with PS. Taking advantage of the tendency for heteroplasmy to change with cell passage, we isolated isogenic PS-iPS cells without detectable levels of deleted mtDNA. We found that PS-iPS cells carrying a high burden of deleted mtDNA displayed differences in growth, mitochondrial function, and hematopoietic phenotype when differentiated in vitro, compared to isogenic iPS cells without deleted mtDNA. Our results demonstrate that reprogramming somatic cells from patients with mtDNA disorders can yield pluripotent stem cells with varying burdens of heteroplasmy that might be useful in the study and treatment of mitochondrial diseases." @default.
• W2032181723 created "2016-06-24" @default.
• W2032181723 creator A5006370557 @default.
• W2032181723 creator A5011922655 @default.
• W2032181723 creator A5024465077 @default.
• W2032181723 creator A5029231445 @default.
• W2032181723 creator A5032646321 @default.
• W2032181723 creator A5037067745 @default.
• W2032181723 creator A5040943880 @default.
• W2032181723 creator A5049150120 @default.
• W2032181723 creator A5050008040 @default.
• W2032181723 creator A5059348374 @default.
• W2032181723 creator A5060648430 @default.
• W2032181723 creator A5064815634 @default.
• W2032181723 creator A5086688631 @default.
• W2032181723 creator A5086812657 @default.
• W2032181723 creator A5087807841 @default.
• W2032181723 date "2013-07-01" @default.
• W2032181723 modified "2023-10-01" @default.
• W2032181723 title "Induced Pluripotent Stem Cells with a Mitochondrial DNA Deletion" @default.
• W2032181723 cites W1629240889 @default.
• W2032181723 cites W1720754255 @default.
• W2032181723 cites W1990368793 @default.
• W2032181723 cites W1993638375 @default.
• W2032181723 cites W2002179012 @default.
• W2032181723 cites W2017347785 @default.
• W2032181723 cites W2019019085 @default.
• W2032181723 cites W2025192477 @default.
• W2032181723 cites W2025738240 @default.
• W2032181723 cites W2032628875 @default.
• W2032181723 cites W2047262629 @default.
• W2032181723 cites W2050626041 @default.
• W2032181723 cites W2062840593 @default.
• W2032181723 cites W2071709882 @default.
• W2032181723 cites W2074832119 @default.
• W2032181723 cites W2077414996 @default.
• W2032181723 cites W2082144941 @default.
• W2032181723 cites W2082304305 @default.
• W2032181723 cites W2087284699 @default.
• W2032181723 cites W2090104357 @default.
• W2032181723 cites W2098108136 @default.
• W2032181723 cites W2106464604 @default.
• W2032181723 cites W2110288755 @default.
• W2032181723 cites W2133486230 @default.
• W2032181723 cites W2134846845 @default.
• W2032181723 cites W2138977668 @default.
• W2032181723 cites W2142046859 @default.
• W2032181723 cites W2150197150 @default.
• W2032181723 cites W2160943807 @default.
• W2032181723 cites W2331682612 @default.
• W2032181723 cites W2357340708 @default.
• W2032181723 cites W4245088748 @default.
• W2032181723 cites W4361804493 @default.
• W2032181723 doi "https://doi.org/10.1002/stem.1354" @default.
• W2032181723 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3692613" @default.
• W2032181723 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23400930" @default.
• W2032181723 hasPublicationYear "2013" @default.
• W2032181723 type Work @default.
• W2032181723 sameAs 2032181723 @default.
• W2032181723 citedByCount "91" @default.
• W2032181723 countsByYear W20321817232013 @default.
• W2032181723 countsByYear W20321817232014 @default.
• W2032181723 countsByYear W20321817232015 @default.
• W2032181723 countsByYear W20321817232016 @default.
• W2032181723 countsByYear W20321817232017 @default.
• W2032181723 countsByYear W20321817232018 @default.
• W2032181723 countsByYear W20321817232019 @default.
• W2032181723 countsByYear W20321817232020 @default.
• W2032181723 countsByYear W20321817232021 @default.
• W2032181723 countsByYear W20321817232022 @default.
• W2032181723 countsByYear W20321817232023 @default.
• W2032181723 crossrefType "journal-article" @default.
• W2032181723 hasAuthorship W2032181723A5006370557 @default.
• W2032181723 hasAuthorship W2032181723A5011922655 @default.
• W2032181723 hasAuthorship W2032181723A5024465077 @default.
• W2032181723 hasAuthorship W2032181723A5029231445 @default.
• W2032181723 hasAuthorship W2032181723A5032646321 @default.
• W2032181723 hasAuthorship W2032181723A5037067745 @default.
• W2032181723 hasAuthorship W2032181723A5040943880 @default.
• W2032181723 hasAuthorship W2032181723A5049150120 @default.
• W2032181723 hasAuthorship W2032181723A5050008040 @default.
• W2032181723 hasAuthorship W2032181723A5059348374 @default.
• W2032181723 hasAuthorship W2032181723A5060648430 @default.
• W2032181723 hasAuthorship W2032181723A5064815634 @default.
• W2032181723 hasAuthorship W2032181723A5086688631 @default.
• W2032181723 hasAuthorship W2032181723A5086812657 @default.
• W2032181723 hasAuthorship W2032181723A5087807841 @default.
• W2032181723 hasBestOaLocation W20321817231 @default.
• W2032181723 hasConcept C104317684 @default.
• W2032181723 hasConcept C107459253 @default.
• W2032181723 hasConcept C109159458 @default.
• W2032181723 hasConcept C127716648 @default.
• W2032181723 hasConcept C134305767 @default.
• W2032181723 hasConcept C145103041 @default.
• W2032181723 hasConcept C1491633281 @default.
• W2032181723 hasConcept C153911025 @default.
• W2032181723 hasConcept C181561989 @default.
• W2032181723 hasConcept C24586158 @default.

• next