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• W2032183963 abstract "ObjectiveBrain-derived neurotrophic factor (BDNF) and neurotrophin-4 (NT4) are both produced in the endometrium and are implicated in feto-placental development. We evaluated whether levels of BDNF and NT4 predicted outcome of IVF pregnancies.DesignRetrospective cohort study of 256 women undergoing IVF, matched by age and outcome. Outcomes were: 69(27%) term delivery, 24(9%) spontaneous abortion, 43(17%) ectopic pregnancy, 52(20%) biochemical pregnancy, and 68(27%) women who did not become pregnant.Materials and MethodsSera from days 24 (1 week after embryo transfer) and 28 (day of pregnancy test) were tested for BDNF and NT4 by quantitative ELISAs. Investigators were blinded to outcome. Data were analyzed by Mann Whitney U for non-parametric data and by Student's t test for normally distributed data. P values <0.05 were considered statistically significant.ResultsTabled 1OutcomeNeurotrophin (pg/ml)BDNF1NT42Day 24 (p-value)Day 28 (p-value)Day 24 (p-value)Day 28 (p-value)Live Birth976.3989.220.444.96Early pregnancy loss (SAb, EP, BC)769 (<0.0001)770.9 (<0.0001)122 (ns)699.7 (0.008)Ectopic v. live births726.6 (<0.001)701.9 (<0.0001)136 (0.049)4162 (0.003)Live birth v. all others(<0.0001)(<0.0001)(ns)(0.047)Ectopic v. all others(<0.0001)(0.009)(ns)(0.014)Ectopic v. other pregnancies(<0.0001)(0.022)(ns)(0.025)1Student's t test;2Mann Whitney U;ns=not significant;SAb=spontaneous abortion;EP=ectopic pregnancy;BC=biochemical. Open table in a new tab ConclusionBDNF and NT4 are predictive of IVF pregnancy outcomes four days prior to the first pregnancy test. Moreover, they may also identify patients at risk for ectopic pregnancy. Although BDNF and NT4 function via similar tyrosine kinase mechanisms, this data suggests that there may be subtle differences in their mode of action and function in pregnancy. ObjectiveBrain-derived neurotrophic factor (BDNF) and neurotrophin-4 (NT4) are both produced in the endometrium and are implicated in feto-placental development. We evaluated whether levels of BDNF and NT4 predicted outcome of IVF pregnancies. Brain-derived neurotrophic factor (BDNF) and neurotrophin-4 (NT4) are both produced in the endometrium and are implicated in feto-placental development. We evaluated whether levels of BDNF and NT4 predicted outcome of IVF pregnancies. DesignRetrospective cohort study of 256 women undergoing IVF, matched by age and outcome. Outcomes were: 69(27%) term delivery, 24(9%) spontaneous abortion, 43(17%) ectopic pregnancy, 52(20%) biochemical pregnancy, and 68(27%) women who did not become pregnant. Retrospective cohort study of 256 women undergoing IVF, matched by age and outcome. Outcomes were: 69(27%) term delivery, 24(9%) spontaneous abortion, 43(17%) ectopic pregnancy, 52(20%) biochemical pregnancy, and 68(27%) women who did not become pregnant. Materials and MethodsSera from days 24 (1 week after embryo transfer) and 28 (day of pregnancy test) were tested for BDNF and NT4 by quantitative ELISAs. Investigators were blinded to outcome. Data were analyzed by Mann Whitney U for non-parametric data and by Student's t test for normally distributed data. P values <0.05 were considered statistically significant. Sera from days 24 (1 week after embryo transfer) and 28 (day of pregnancy test) were tested for BDNF and NT4 by quantitative ELISAs. Investigators were blinded to outcome. Data were analyzed by Mann Whitney U for non-parametric data and by Student's t test for normally distributed data. P values <0.05 were considered statistically significant. ResultsTabled 1OutcomeNeurotrophin (pg/ml)BDNF1NT42Day 24 (p-value)Day 28 (p-value)Day 24 (p-value)Day 28 (p-value)Live Birth976.3989.220.444.96Early pregnancy loss (SAb, EP, BC)769 (<0.0001)770.9 (<0.0001)122 (ns)699.7 (0.008)Ectopic v. live births726.6 (<0.001)701.9 (<0.0001)136 (0.049)4162 (0.003)Live birth v. all others(<0.0001)(<0.0001)(ns)(0.047)Ectopic v. all others(<0.0001)(0.009)(ns)(0.014)Ectopic v. other pregnancies(<0.0001)(0.022)(ns)(0.025)1Student's t test;2Mann Whitney U;ns=not significant;SAb=spontaneous abortion;EP=ectopic pregnancy;BC=biochemical. Open table in a new tab 1Student's t test;2Mann Whitney U;ns=not significant;SAb=spontaneous abortion;EP=ectopic pregnancy;BC=biochemical. ConclusionBDNF and NT4 are predictive of IVF pregnancy outcomes four days prior to the first pregnancy test. Moreover, they may also identify patients at risk for ectopic pregnancy. Although BDNF and NT4 function via similar tyrosine kinase mechanisms, this data suggests that there may be subtle differences in their mode of action and function in pregnancy. BDNF and NT4 are predictive of IVF pregnancy outcomes four days prior to the first pregnancy test. Moreover, they may also identify patients at risk for ectopic pregnancy. Although BDNF and NT4 function via similar tyrosine kinase mechanisms, this data suggests that there may be subtle differences in their mode of action and function in pregnancy." @default.
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• W2032183963 date "2013-09-01" @default.
• W2032183963 modified "2023-10-14" @default.
• W2032183963 title "Neurotrophins as markers of IVF pregnancy outcome" @default.
• W2032183963 doi "https://doi.org/10.1016/j.fertnstert.2013.07.184" @default.
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