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• W2032185525 abstract "Background.Women with premenopausal breast cancer may face treatment-related infertility and have a higher likelihood of a BRCA mutation, which may affect their attitudes toward future childbearing. Methods. Premenopausal women were invited to participate in a questionnaire study administered before and after BRCA genetic testing. We used the Impact of Event Scale (IES) to evaluatethepre-andpost-testingimpactofcancerorcarrying aBRCAmutationonattitudestowardfuturechildbearing.The likelihood of pursuing prenatal diagnosis (PND) or preimplantation genetic diagnosis (PGD) was also assessed in this setting. Univariate analyses determined factors contributing to attitudes toward future childbearing and likelihood of PND or PGD. Results. One hundred forty-eight pretesting and 114 posttesting questionnaires were completed. Women with a personalhistoryofbreastcancerhadlesschangeinIESthanthose with no history of breast cancer (p 5 .003). The 18 BRCApositive women had a greater change in IES than the BRCAnegative women (p 5 .005). After testing, 31% and 24% of womenwouldusePNDandPGD,respectively.BRCAresultsdid not significantly affect attitudes toward PND/PGD. Conclusion. BRCA results and history of breast cancer affect the psychological impact on future childbearing. Intentions to undergo PND or PGD do not appear to change after disclosure of BRCA results. Additional counseling for patients who have undergone BRCA testing may be warranted to educate patients about available fertility preservation options.The Oncologist 2014;19:1–8 Implications for Practice: The purpose of this study was to evaluate how BRCA genetic test result disclosure and patient characteristicsinfluenceattitudesaboutpreimplantationgeneticdiagnosisandfuturechildbearing.Suchanunderstandingcould significantlyimprovetheabilityofgeneticcounselorsandhealthcareproviderstocounselwomenwithpossibleoridentifiedBRCA mutations. Capturing the opinions on this topic, both before genetic counseling and after result disclosure, can help determine effectsondecisionstowardsfuturereproduction.Theseresultshelphealthcareprofessionalsprovidetheappropriateinformation" @default.
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• W2032185525 date "2011-12-15" @default.
• W2032185525 modified "2023-10-14" @default.
• W2032185525 title "P2-13-05: Breast Cancer, BRCA Mutations and Attitudes Regarding Pregnancy and Preimplantation Genetic Diagnosis." @default.
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• W2032185525 doi "https://doi.org/10.1158/0008-5472.sabcs11-p2-13-05" @default.
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