FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2032185656> ?p ?o ?g. }

• W2032185656 endingPage "26032" @default.
• W2032185656 startingPage "26022" @default.
• W2032185656 abstract "Proteins bound to the poly(A) tail of mRNA transcripts, called poly(A)-binding proteins (Pabs), play critical roles in regulating RNA stability, translation, and nuclear export. Like many mRNA-binding proteins that modulate post-transcriptional processing events, assigning specific functions to Pabs is challenging because these processing events are tightly coupled to one another. To investigate the role that a novel class of zinc finger-containing Pabs plays in these coupled processes, we defined the mode of polyadenosine RNA recognition for the conserved Saccharomyces cerevisiae Nab2 protein and assessed in vivo consequences caused by disruption of RNA binding. The polyadenosine RNA recognition domain of Nab2 consists of three tandem Cys-Cys-Cys-His (CCCH) zinc fingers. Cells expressing mutant Nab2 proteins with decreased binding to polyadenosine RNA show growth defects as well as defects in poly(A) tail length but do not accumulate poly(A) RNA in the nucleus. We also demonstrate genetic interactions between mutant nab2 alleles and mutant alleles of the mRNA 3′-end processing machinery. Together, these data provide strong evidence that Nab2 binding to RNA is critical for proper control of poly(A) tail length. Proteins bound to the poly(A) tail of mRNA transcripts, called poly(A)-binding proteins (Pabs), play critical roles in regulating RNA stability, translation, and nuclear export. Like many mRNA-binding proteins that modulate post-transcriptional processing events, assigning specific functions to Pabs is challenging because these processing events are tightly coupled to one another. To investigate the role that a novel class of zinc finger-containing Pabs plays in these coupled processes, we defined the mode of polyadenosine RNA recognition for the conserved Saccharomyces cerevisiae Nab2 protein and assessed in vivo consequences caused by disruption of RNA binding. The polyadenosine RNA recognition domain of Nab2 consists of three tandem Cys-Cys-Cys-His (CCCH) zinc fingers. Cells expressing mutant Nab2 proteins with decreased binding to polyadenosine RNA show growth defects as well as defects in poly(A) tail length but do not accumulate poly(A) RNA in the nucleus. We also demonstrate genetic interactions between mutant nab2 alleles and mutant alleles of the mRNA 3′-end processing machinery. Together, these data provide strong evidence that Nab2 binding to RNA is critical for proper control of poly(A) tail length." @default.
• W2032185656 created "2016-06-24" @default.
• W2032185656 creator A5009494191 @default.
• W2032185656 creator A5017446481 @default.
• W2032185656 creator A5026938176 @default.
• W2032185656 creator A5027064815 @default.
• W2032185656 creator A5031226363 @default.
• W2032185656 creator A5038570641 @default.
• W2032185656 creator A5061904626 @default.
• W2032185656 creator A5081798922 @default.
• W2032185656 date "2010-08-01" @default.
• W2032185656 modified "2023-10-16" @default.
• W2032185656 title "Recognition of Polyadenosine RNA by the Zinc Finger Domain of Nuclear Poly(A) RNA-binding Protein 2 (Nab2) Is Required for Correct mRNA 3′-End Formation*" @default.
• W2032185656 cites W1559808711 @default.
• W2032185656 cites W1966017154 @default.
• W2032185656 cites W1971794652 @default.
• W2032185656 cites W1973984431 @default.
• W2032185656 cites W1975616778 @default.
• W2032185656 cites W1979632388 @default.
• W2032185656 cites W1986978376 @default.
• W2032185656 cites W2001932825 @default.
• W2032185656 cites W2004824571 @default.
• W2032185656 cites W2010081999 @default.
• W2032185656 cites W2012097856 @default.
• W2032185656 cites W2014739284 @default.
• W2032185656 cites W2015175027 @default.
• W2032185656 cites W2015350814 @default.
• W2032185656 cites W2015506926 @default.
• W2032185656 cites W2030677655 @default.
• W2032185656 cites W2031211590 @default.
• W2032185656 cites W2032117059 @default.
• W2032185656 cites W2033200059 @default.
• W2032185656 cites W2058949200 @default.
• W2032185656 cites W2066377184 @default.
• W2032185656 cites W2070686658 @default.
• W2032185656 cites W2078655896 @default.
• W2032185656 cites W2081507744 @default.
• W2032185656 cites W2088525343 @default.
• W2032185656 cites W2099905512 @default.
• W2032185656 cites W2100057937 @default.
• W2032185656 cites W2102309307 @default.
• W2032185656 cites W2103856927 @default.
• W2032185656 cites W2124007474 @default.
• W2032185656 cites W2124254407 @default.
• W2032185656 cites W2125624608 @default.
• W2032185656 cites W2127701573 @default.
• W2032185656 cites W2132316587 @default.
• W2032185656 cites W2138459463 @default.
• W2032185656 cites W2152327726 @default.
• W2032185656 cites W2169333620 @default.
• W2032185656 cites W2170526080 @default.
• W2032185656 cites W2171788412 @default.
• W2032185656 doi "https://doi.org/10.1074/jbc.m110.141127" @default.
• W2032185656 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2924000" @default.
• W2032185656 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/20554526" @default.
• W2032185656 hasPublicationYear "2010" @default.
• W2032185656 type Work @default.
• W2032185656 sameAs 2032185656 @default.
• W2032185656 citedByCount "39" @default.
• W2032185656 countsByYear W20321856562012 @default.
• W2032185656 countsByYear W20321856562013 @default.
• W2032185656 countsByYear W20321856562014 @default.
• W2032185656 countsByYear W20321856562015 @default.
• W2032185656 countsByYear W20321856562016 @default.
• W2032185656 countsByYear W20321856562017 @default.
• W2032185656 countsByYear W20321856562018 @default.
• W2032185656 countsByYear W20321856562019 @default.
• W2032185656 countsByYear W20321856562020 @default.
• W2032185656 countsByYear W20321856562021 @default.
• W2032185656 countsByYear W20321856562022 @default.
• W2032185656 countsByYear W20321856562023 @default.
• W2032185656 crossrefType "journal-article" @default.
• W2032185656 hasAuthorship W2032185656A5009494191 @default.
• W2032185656 hasAuthorship W2032185656A5017446481 @default.
• W2032185656 hasAuthorship W2032185656A5026938176 @default.
• W2032185656 hasAuthorship W2032185656A5027064815 @default.
• W2032185656 hasAuthorship W2032185656A5031226363 @default.
• W2032185656 hasAuthorship W2032185656A5038570641 @default.
• W2032185656 hasAuthorship W2032185656A5061904626 @default.
• W2032185656 hasAuthorship W2032185656A5081798922 @default.
• W2032185656 hasBestOaLocation W20321856561 @default.
• W2032185656 hasConcept C104317684 @default.
• W2032185656 hasConcept C105580179 @default.
• W2032185656 hasConcept C149364088 @default.
• W2032185656 hasConcept C153911025 @default.
• W2032185656 hasConcept C162092063 @default.
• W2032185656 hasConcept C21786251 @default.
• W2032185656 hasConcept C24284526 @default.
• W2032185656 hasConcept C41282012 @default.
• W2032185656 hasConcept C55493867 @default.
• W2032185656 hasConcept C67705224 @default.
• W2032185656 hasConcept C86339819 @default.
• W2032185656 hasConcept C86803240 @default.
• W2032185656 hasConcept C95444343 @default.
• W2032185656 hasConceptScore W2032185656C104317684 @default.
• W2032185656 hasConceptScore W2032185656C105580179 @default.
• W2032185656 hasConceptScore W2032185656C149364088 @default.
• W2032185656 hasConceptScore W2032185656C153911025 @default.

• next