Matches in SemOpenAlex for { <https://semopenalex.org/work/W2032187386> ?p ?o ?g. }
- W2032187386 abstract "Reversible modification of histone tails is a regulatory step in chromatin remodeling. The N-terminal tails of histones are signaling platforms that carry amino acid residues for post-translational modification and contribute to chromosomal higher order structure. These modifications are performed by a number of chromatin modulators such as histone (h) acetyltransferase, h-deacetylase, h-methyltransferase and h-kinase. Large numbers of these enzymes as well as other chromatin-associated proteins share the bromodomain, a signature protein motif. Structural studies reveal not only wide structural conservation of bromodomains but also envision a possible role of this domain in the recognition of specific modified residues in the histone tails. The widespread presence of bromodomains in leukemogenic and cancer genes has provided a fundamental tool for studies of the role of epigenetic and chromatin remodeling in malignant diseases." @default.
- W2032187386 created "2016-06-24" @default.
- W2032187386 creator A5036009946 @default.
- W2032187386 date "2001-01-01" @default.
- W2032187386 modified "2023-09-26" @default.
- W2032187386 title "The bromodomain: a chromatin browser?" @default.
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- W2032187386 doi "https://doi.org/10.2741/filetici" @default.
- W2032187386 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/11487466" @default.
- W2032187386 hasPublicationYear "2001" @default.
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