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• W2032189489 abstract "One of the central questions in the biophysics of the mammalian cochlea is determining the contributions of the two active processes, prestin-based somatic motility and hair bundle (HB) motility, to cochlear amplification. HB force generation is linked to fast adaptation of the transduction current via a calcium-dependent process and somatic force generation is driven by the depolarization caused by the transduction current. In this article, we construct a global mechanical-electrical-acoustical mathematical model of the cochlea based on a three-dimensional fluid representation. The global cochlear model is coupled to linearizations of nonlinear somatic motility and HB activity as well as to the micromechanics of the passive structural and electrical elements of the cochlea. We find that the active HB force alone is not sufficient to power high frequency cochlear amplification. However, somatic motility can overcome resistor-capacitor filtering by the basolateral membrane and deliver sufficient mechanical energy for amplification at basal locations. The results suggest a new theory for high frequency active cochlear mechanics, in which fast adaptation controls the transduction channel sensitivity and thereby the magnitude of the energy delivered by somatic motility." @default.
• W2032189489 created "2016-06-24" @default.
• W2032189489 creator A5000190966 @default.
• W2032189489 creator A5074962723 @default.
• W2032189489 date "2011-06-01" @default.
• W2032189489 modified "2023-09-27" @default.
• W2032189489 title "Coupling Active Hair Bundle Mechanics, Fast Adaptation, and Somatic Motility in a Cochlear Model" @default.
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• W2032189489 doi "https://doi.org/10.1016/j.bpj.2011.04.049" @default.
• W2032189489 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3117151" @default.
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