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- W2032207988 abstract "[3H]RP 62203 and [3H]SR 46349B binding were assessed in rat brain after intravenous (iv) injection. The distribution of specific binding of each radioligand corresponded to the known distribution of 5-HT2A receptor sites. The maximum signals (counts/g tissue over counts/g cerebellum) given by [3H]RP 62203 and [3H]SR 46349B were 9.0 ± 0.9 at 60 min and 3.2 ± 0.3 at 30 min, respectively, in frontopolar cortex. Specific binding was quantified using a reference-tissue compartment model. RP 62203 appears to be more suitable than SR 46349B for development as a PET radioligand on the basis of its higher receptor specific signal." @default.
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- W2032207988 date "1996-04-01" @default.
- W2032207988 modified "2023-09-25" @default.
- W2032207988 title "Development of central 5-HT2A receptor radioligands for PET: Comparison of [3H]RP 62203 and [3H]SR 46349B kinetics in rat brain" @default.
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- W2032207988 doi "https://doi.org/10.1016/0969-8051(95)02053-5" @default.
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