FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2032217040> ?p ?o ?g. }

• W2032217040 endingPage "1339" @default.
• W2032217040 startingPage "1329" @default.
• W2032217040 abstract "Proper folding and maintenance of the native structure are central to protein function and are assisted by a family of proteins called chaperones. Calreticulin and calnexin are ER resident chaperones well conserved from worm to human. Calreticulin/calnexin knock-out mice exhibit a severe phenotype, whereas in Caenorhabditis elegans, calreticulin [crt-1(jh101)]- and calnexin [cnx-1(nr2009)]-null mutant worms exhibit only a mild phenotype, suggesting the possible existence of alternative chaperone machinery that can compensate for the deficiency of calreticulin and/or calnexin. In order to rapidly identify the compensatory chaperone components involved in this process, we analyzed the proteome of crt-1(jh101) mutants and [crt-1(jh101);cnx-1(nr2009)] double mutants. When grown at 20 degrees C, we found that five proteins were up-regulated and two proteins were down-regulated in crt-1(jh101) mutants; nine proteins were up-regulated and five proteins were down-regulated in [crt-1(jh101);cnx-1(nr2009)] double mutants. In addition, elevation of the cultivation temperature to 25 degrees C, which is still permissive to growth but causes specific defects in mutants, led to the identification of several additional proteins. Interestingly, the consistent increment of heat shock protein-70 family members (hsp70) together with protein disulfide isomerase (PDI) at all the examined conditions suggests the possible compensatory function imparted by hsp70 and PDI family members in the absence of calreticulin and/or calnexin." @default.
• W2032217040 created "2016-06-24" @default.
• W2032217040 creator A5006211257 @default.
• W2032217040 creator A5009641747 @default.
• W2032217040 creator A5014265429 @default.
• W2032217040 creator A5026360578 @default.
• W2032217040 creator A5058372327 @default.
• W2032217040 creator A5068640140 @default.
• W2032217040 creator A5091721506 @default.
• W2032217040 date "2006-02-01" @default.
• W2032217040 modified "2023-10-07" @default.
• W2032217040 title "Alternative chaperone machinery may compensate for calreticulin/calnexin deficiency inCaenorhabditis elegans" @default.
• W2032217040 cites W1839183617 @default.
• W2032217040 cites W1965843055 @default.
• W2032217040 cites W1970007744 @default.
• W2032217040 cites W1978986484 @default.
• W2032217040 cites W1989203765 @default.
• W2032217040 cites W1992106121 @default.
• W2032217040 cites W1999456217 @default.
• W2032217040 cites W2016604591 @default.
• W2032217040 cites W2021803481 @default.
• W2032217040 cites W2036677133 @default.
• W2032217040 cites W2051690692 @default.
• W2032217040 cites W2052390575 @default.
• W2032217040 cites W2053021234 @default.
• W2032217040 cites W2053885962 @default.
• W2032217040 cites W2064507821 @default.
• W2032217040 cites W2085580153 @default.
• W2032217040 cites W2085628457 @default.
• W2032217040 cites W2086142693 @default.
• W2032217040 cites W2100701404 @default.
• W2032217040 cites W2106305244 @default.
• W2032217040 cites W2107601804 @default.
• W2032217040 cites W2108126393 @default.
• W2032217040 cites W2119363278 @default.
• W2032217040 cites W2128720297 @default.
• W2032217040 cites W2278551788 @default.
• W2032217040 cites W4245305755 @default.
• W2032217040 doi "https://doi.org/10.1002/pmic.200500320" @default.
• W2032217040 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/16404716" @default.
• W2032217040 hasPublicationYear "2006" @default.
• W2032217040 type Work @default.
• W2032217040 sameAs 2032217040 @default.
• W2032217040 citedByCount "20" @default.
• W2032217040 countsByYear W20322170402012 @default.
• W2032217040 countsByYear W20322170402013 @default.
• W2032217040 countsByYear W20322170402014 @default.
• W2032217040 countsByYear W20322170402016 @default.
• W2032217040 countsByYear W20322170402017 @default.
• W2032217040 countsByYear W20322170402018 @default.
• W2032217040 countsByYear W20322170402022 @default.
• W2032217040 crossrefType "journal-article" @default.
• W2032217040 hasAuthorship W2032217040A5006211257 @default.
• W2032217040 hasAuthorship W2032217040A5009641747 @default.
• W2032217040 hasAuthorship W2032217040A5014265429 @default.
• W2032217040 hasAuthorship W2032217040A5026360578 @default.
• W2032217040 hasAuthorship W2032217040A5058372327 @default.
• W2032217040 hasAuthorship W2032217040A5068640140 @default.
• W2032217040 hasAuthorship W2032217040A5091721506 @default.
• W2032217040 hasConcept C104317684 @default.
• W2032217040 hasConcept C104397665 @default.
• W2032217040 hasConcept C130361206 @default.
• W2032217040 hasConcept C142724271 @default.
• W2032217040 hasConcept C143065580 @default.
• W2032217040 hasConcept C158617107 @default.
• W2032217040 hasConcept C204328495 @default.
• W2032217040 hasConcept C205260736 @default.
• W2032217040 hasConcept C2775962898 @default.
• W2032217040 hasConcept C2779926675 @default.
• W2032217040 hasConcept C47450691 @default.
• W2032217040 hasConcept C5098756 @default.
• W2032217040 hasConcept C54355233 @default.
• W2032217040 hasConcept C68991219 @default.
• W2032217040 hasConcept C71924100 @default.
• W2032217040 hasConcept C86803240 @default.
• W2032217040 hasConcept C95444343 @default.
• W2032217040 hasConceptScore W2032217040C104317684 @default.
• W2032217040 hasConceptScore W2032217040C104397665 @default.
• W2032217040 hasConceptScore W2032217040C130361206 @default.
• W2032217040 hasConceptScore W2032217040C142724271 @default.
• W2032217040 hasConceptScore W2032217040C143065580 @default.
• W2032217040 hasConceptScore W2032217040C158617107 @default.
• W2032217040 hasConceptScore W2032217040C204328495 @default.
• W2032217040 hasConceptScore W2032217040C205260736 @default.
• W2032217040 hasConceptScore W2032217040C2775962898 @default.
• W2032217040 hasConceptScore W2032217040C2779926675 @default.
• W2032217040 hasConceptScore W2032217040C47450691 @default.
• W2032217040 hasConceptScore W2032217040C5098756 @default.
• W2032217040 hasConceptScore W2032217040C54355233 @default.
• W2032217040 hasConceptScore W2032217040C68991219 @default.
• W2032217040 hasConceptScore W2032217040C71924100 @default.
• W2032217040 hasConceptScore W2032217040C86803240 @default.
• W2032217040 hasConceptScore W2032217040C95444343 @default.
• W2032217040 hasIssue "4" @default.
• W2032217040 hasLocation W20322170401 @default.
• W2032217040 hasLocation W20322170402 @default.
• W2032217040 hasOpenAccess W2032217040 @default.
• W2032217040 hasPrimaryLocation W20322170401 @default.

• next