FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2032220003> ?p ?o ?g. }

• W2032220003 endingPage "231" @default.
• W2032220003 startingPage "221" @default.
• W2032220003 abstract "Calcitonin gene-related peptide (CGRP) shares about 46% and 20% amino acid sequence homology with islet amyloid polypeptide (IAPP) and salmon calcitonin (sCT). We investigated whether these related peptides could cross-react with the specific binding of 125I-[His]hCGRP I to the CGRP receptor in hamster insulinoma cell membranes. A rapid dissociation of membrane bound 125I-[His]hCGRP I could be induced in the presence of 1 μM chicken CGRP (cCGRP). The specific 125I-[His]hCGRP I binding was inhibited by the related peptides and their half-maximal inhibitory concentrations (IC50) were: cCGRP (0.1 nM), rat CGRP I and human CGRP I and II (1.0–2.0 nM), fragment of hCGRP I (8–37) (150 nM), human IAPP (440 nM). The non-amidated form of hIAPP; human diabetes-associated peptide (hDAP) did not inhibit the binding of 125I-[His]hCGRP I and sCT was only effective at a high concentration (1 μM). Binding of 125I-[His]hCGRP I was dose dependently inhibited by guanosine-5′-O-(3-thiotriphosphate) or (GTPγS) and a 70% reduction of binding was obtained with 0.1 mM GTPγS. The IC50 value of cCGRP (0.1 nM) was increased 100-fold in the presence of 0.1 mM GTPγS. Human CGRP I and cCGRP at 2.5 μM did not stimulate the activity of hamster insulinoma cell membranes adenylate cyclase, while glucagon (1 μM) induced a 2-fold increase. Thus, specific CGRP receptors present in hamster β cells are associated with G protein (s) and IAPP can interact with these receptors. These results and the observation that cCGRP and hCGRP I did not influence adenylate cyclase activity provide further evidence for CGRP receptor subtypes." @default.
• W2032220003 created "2016-06-24" @default.
• W2032220003 creator A5004317162 @default.
• W2032220003 creator A5007464091 @default.
• W2032220003 creator A5034429155 @default.
• W2032220003 date "1993-08-01" @default.
• W2032220003 modified "2023-10-15" @default.
• W2032220003 title "Characterization of specific calcitonin gene related peptide receptors present in hamster pancreatic β cells" @default.
• W2032220003 cites W139040250 @default.
• W2032220003 cites W1613233258 @default.
• W2032220003 cites W183853873 @default.
• W2032220003 cites W1965214206 @default.
• W2032220003 cites W1971937203 @default.
• W2032220003 cites W1975696039 @default.
• W2032220003 cites W1983785126 @default.
• W2032220003 cites W1986338276 @default.
• W2032220003 cites W1988700235 @default.
• W2032220003 cites W1999979603 @default.
• W2032220003 cites W2019337085 @default.
• W2032220003 cites W2030249025 @default.
• W2032220003 cites W2035581625 @default.
• W2032220003 cites W2036550737 @default.
• W2032220003 cites W2038276612 @default.
• W2032220003 cites W2046731801 @default.
• W2032220003 cites W2056955251 @default.
• W2032220003 cites W2067820229 @default.
• W2032220003 cites W2068198082 @default.
• W2032220003 cites W2070049849 @default.
• W2032220003 cites W2082400476 @default.
• W2032220003 cites W2086369261 @default.
• W2032220003 cites W2086403888 @default.
• W2032220003 cites W2087003816 @default.
• W2032220003 cites W2116739144 @default.
• W2032220003 cites W2120974472 @default.
• W2032220003 cites W2129983971 @default.
• W2032220003 cites W2152848856 @default.
• W2032220003 cites W2157442995 @default.
• W2032220003 cites W4293247451 @default.
• W2032220003 doi "https://doi.org/10.1007/bf01123504" @default.
• W2032220003 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/8305633" @default.
• W2032220003 hasPublicationYear "1993" @default.
• W2032220003 type Work @default.
• W2032220003 sameAs 2032220003 @default.
• W2032220003 citedByCount "10" @default.
• W2032220003 countsByYear W20322200032015 @default.
• W2032220003 countsByYear W20322200032016 @default.
• W2032220003 countsByYear W20322200032020 @default.
• W2032220003 crossrefType "journal-article" @default.
• W2032220003 hasAuthorship W2032220003A5004317162 @default.
• W2032220003 hasAuthorship W2032220003A5007464091 @default.
• W2032220003 hasAuthorship W2032220003A5034429155 @default.
• W2032220003 hasConcept C118303440 @default.
• W2032220003 hasConcept C118716 @default.
• W2032220003 hasConcept C126322002 @default.
• W2032220003 hasConcept C134018914 @default.
• W2032220003 hasConcept C163170386 @default.
• W2032220003 hasConcept C165220095 @default.
• W2032220003 hasConcept C170493617 @default.
• W2032220003 hasConcept C175656101 @default.
• W2032220003 hasConcept C181199279 @default.
• W2032220003 hasConcept C185592680 @default.
• W2032220003 hasConcept C2777995097 @default.
• W2032220003 hasConcept C2778575167 @default.
• W2032220003 hasConcept C2779281246 @default.
• W2032220003 hasConcept C2779306644 @default.
• W2032220003 hasConcept C2779627488 @default.
• W2032220003 hasConcept C2780069284 @default.
• W2032220003 hasConcept C2780705028 @default.
• W2032220003 hasConcept C55493867 @default.
• W2032220003 hasConcept C71924100 @default.
• W2032220003 hasConcept C80631254 @default.
• W2032220003 hasConcept C86803240 @default.
• W2032220003 hasConceptScore W2032220003C118303440 @default.
• W2032220003 hasConceptScore W2032220003C118716 @default.
• W2032220003 hasConceptScore W2032220003C126322002 @default.
• W2032220003 hasConceptScore W2032220003C134018914 @default.
• W2032220003 hasConceptScore W2032220003C163170386 @default.
• W2032220003 hasConceptScore W2032220003C165220095 @default.
• W2032220003 hasConceptScore W2032220003C170493617 @default.
• W2032220003 hasConceptScore W2032220003C175656101 @default.
• W2032220003 hasConceptScore W2032220003C181199279 @default.
• W2032220003 hasConceptScore W2032220003C185592680 @default.
• W2032220003 hasConceptScore W2032220003C2777995097 @default.
• W2032220003 hasConceptScore W2032220003C2778575167 @default.
• W2032220003 hasConceptScore W2032220003C2779281246 @default.
• W2032220003 hasConceptScore W2032220003C2779306644 @default.
• W2032220003 hasConceptScore W2032220003C2779627488 @default.
• W2032220003 hasConceptScore W2032220003C2780069284 @default.
• W2032220003 hasConceptScore W2032220003C2780705028 @default.
• W2032220003 hasConceptScore W2032220003C55493867 @default.
• W2032220003 hasConceptScore W2032220003C71924100 @default.
• W2032220003 hasConceptScore W2032220003C80631254 @default.
• W2032220003 hasConceptScore W2032220003C86803240 @default.
• W2032220003 hasIssue "4" @default.
• W2032220003 hasLocation W20322200031 @default.
• W2032220003 hasLocation W20322200032 @default.
• W2032220003 hasOpenAccess W2032220003 @default.
• W2032220003 hasPrimaryLocation W20322200031 @default.

• next