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- W2032220912 abstract "Myocardial cell death occurs by two distinct pathways—necrosis and apoptosis. The role of necrosis in myocardial cell death has been recognized for more than four decades [ 1 Jennings R.B. Ganote C.E. Structural changes in myocardium during acute ischemia. Circ Res. 1974; 35: 156-172 PubMed Google Scholar , 2 Jennings R.B. Sommers H. Smyth G.A. Flack H.A. Linn H. Myocardial necrosis induced by temporary occlusion of a coronary artery in the dog. Arch Pathol. 1960; 70: 68-78 PubMed Google Scholar ]. The morphologic characteristics of the necrotic (or oncotic) cell death process include: cellular and mitochondrial swelling, chromatin clumping, blebbing and finally sarcolemmal breakdown, the primary indicator of cellular death. The role of apoptotic cell death in myocardial cell death has been recently recognized [ 3 Kajstura J. Cheng W. Reiss K. Clark W.A. Sonnnenblick E.H. Krajewski S. et al. Apoptotic and necrotic myocyte cell deaths are independent contributing variables of infarct size in rats. Lab Invest. 1996; 74: 86-107 PubMed Google Scholar , 4 O'Mahoney M.E. Logue S. Szegezdi E. Stenson-Cox C. Fitzgerald U. Samali A. Hypoxia and ischemia induce nuclear condensation and caspase activation in cardiomyocytes. Ann New York Acad Sci. 2003; 1010: 728-732 Crossref PubMed Scopus (12) Google Scholar , 5 Gottlieb R.A. Gruol D.L. Zhu J.Y. Engler R.L. Preconditioning in rabbit cardiomyocytes. Role of pH, vacuolar proton ATPase, and apoptosis. J Clin Invest. 1996; 97: 2391-2398 Crossref PubMed Scopus (198) Google Scholar ]. The morphologic characteristics of apoptotic cell death include the maintenance of mitochondrial and sarcolemmal integrity, cell shrinkage, chromatin condensation and karyolysis [ 6 Elsasser A. Suzuki K. Schaper J. Unresolved issues regarding the role of apoptosis in the pathogenesis of ischemic injury and heart failure. J Mol Cell Cardiol. 2000; 32: 711-724 Abstract Full Text PDF PubMed Scopus (130) Google Scholar , 7 Elsasser A. Suzuki K. Lorenz-Meyer S. Bode C. Schaper J. The role of apoptosis in myocardial ischemia: a critical appraisal. Basic Res Cardiol. 2001; 96: 219-226 Crossref PubMed Scopus (84) Google Scholar ]. A critical determinant of the contribution of necrosis or apoptosis to myocardial cell death is the level of ATP in the cell during a pathologic event in that the apoptotic process requires ATP and the necrotic process during myocardial ischemia occurs subsequent to ATP depletion [ [8] Leist M. Single B. Castoldi A.F. Kuhnle S. Nicotera P. Intracellular adenosine triphosphate (ATP) concentration: a switch in the decision between apoptosis and necrosis. J Exp Med. 1997; 185: 1481-1486 Crossref PubMed Scopus (1628) Google Scholar ]." @default.
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- W2032220912 date "2004-10-01" @default.
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- W2032220912 title "Anti-oxidants and apoptosis: attenuation of doxorubicin induced cardiomyopathy by carvedilol" @default.
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- W2032220912 doi "https://doi.org/10.1016/j.yjmcc.2004.07.001" @default.
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