FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2032223420> ?p ?o ?g. }

• W2032223420 endingPage "1216" @default.
• W2032223420 startingPage "1209" @default.
• W2032223420 abstract "This article demonstrates that human immunodeficiency virus type 1 (HIV-1) gp120 amplifies the activity of tumor necrosis factor α(TNF-α), a cytokine that stimulates HIV-1 replication through activation of NF-kB. In CD4-positive Jurkat cells, gp120 potentiates TNF-induced NF-kB activation. TNF-mediated activation of NF-kB is known to involve the intracellular formation of reactive oxygen intermediates (ROIs). Accordingly, we examined the influence of gp 120 on the cellular redox state. We found that gp 120-modulated TNF-induced NK-kB activation was inhibited by the antioxidant butylated hydroxyanisole, indicating the involvement of redox-dependent mechanisms. In addition, we showed that gp120 induces intracellular formation of hydrogen peroxide, which is accompanied by a decrease in the ratio of glutathione to glutathione disulfide. In contrast, in the p56lck-deficient J.CaMl.6 T cell line, a derivative of the Jurkat cell line, gp120 was unable to stimulate hydrogen peroxide, to decrease the ratio of GSH to GSSG, and has no effect on TNF-induced NF-kB activation. This demonstrated that p56lck protein tyrosine kinase plays an active role in transmitting a signal that increases the oxidative state of the cell and as a consequence amplifies TNF-mediated NF-kB DNA binding. We have demonstrated that Tat protein decreased both the Mn-dependent Superoxide dismutase (MnSOD) and the cellular glutathione content (GSH). Here we show that, in contrast to Tat, gp120 is unable to inhibit activity and expression of MnSOD and to decrease GSH content. Taken together, our data suggest that gp120 potentiates TNF-induced NF-kB activation by stimulating a signal pathway that involves p56lck and the increased formation of reactive oxygen intermediates such as H2O2. These findings may be relevant for the regulation of HIV-1 replication in T cells." @default.
• W2032223420 created "2016-06-24" @default.
• W2032223420 creator A5003211694 @default.
• W2032223420 creator A5019569172 @default.
• W2032223420 creator A5064138186 @default.
• W2032223420 creator A5082413211 @default.
• W2032223420 creator A5083878777 @default.
• W2032223420 date "1996-09-01" @default.
• W2032223420 modified "2023-09-25" @default.
• W2032223420 title "HIV Type 1 Glycoprotein 120 Amplifies Tumor Necrosis Factor-Induced NF-kB Activation in Jurkat Cells" @default.
• W2032223420 cites W1480581382 @default.
• W2032223420 cites W1506034405 @default.
• W2032223420 cites W1512880547 @default.
• W2032223420 cites W1543517223 @default.
• W2032223420 cites W1558320996 @default.
• W2032223420 cites W1604626968 @default.
• W2032223420 cites W1641869325 @default.
• W2032223420 cites W1965740674 @default.
• W2032223420 cites W1967737680 @default.
• W2032223420 cites W1971057735 @default.
• W2032223420 cites W1981164507 @default.
• W2032223420 cites W1983668987 @default.
• W2032223420 cites W1998421163 @default.
• W2032223420 cites W2012744796 @default.
• W2032223420 cites W2016437687 @default.
• W2032223420 cites W2042161153 @default.
• W2032223420 cites W2043541788 @default.
• W2032223420 cites W2057737390 @default.
• W2032223420 cites W2064914230 @default.
• W2032223420 cites W2073111494 @default.
• W2032223420 cites W2075135942 @default.
• W2032223420 cites W2086725873 @default.
• W2032223420 cites W2089242226 @default.
• W2032223420 cites W2099644089 @default.
• W2032223420 cites W2114466814 @default.
• W2032223420 cites W2119431042 @default.
• W2032223420 cites W2120576246 @default.
• W2032223420 cites W2123030732 @default.
• W2032223420 cites W2151892297 @default.
• W2032223420 cites W2152301236 @default.
• W2032223420 cites W2168870378 @default.
• W2032223420 cites W2180476901 @default.
• W2032223420 cites W2317605718 @default.
• W2032223420 cites W259031618 @default.
• W2032223420 cites W4299401993 @default.
• W2032223420 cites W5978933 @default.
• W2032223420 doi "https://doi.org/10.1089/aid.1996.12.1209" @default.
• W2032223420 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/8870842" @default.
• W2032223420 hasPublicationYear "1996" @default.
• W2032223420 type Work @default.
• W2032223420 sameAs 2032223420 @default.
• W2032223420 citedByCount "38" @default.
• W2032223420 countsByYear W20322234202012 @default.
• W2032223420 countsByYear W20322234202015 @default.
• W2032223420 countsByYear W20322234202016 @default.
• W2032223420 countsByYear W20322234202020 @default.
• W2032223420 countsByYear W20322234202021 @default.
• W2032223420 countsByYear W20322234202022 @default.
• W2032223420 countsByYear W20322234202023 @default.
• W2032223420 crossrefType "journal-article" @default.
• W2032223420 hasAuthorship W2032223420A5003211694 @default.
• W2032223420 hasAuthorship W2032223420A5019569172 @default.
• W2032223420 hasAuthorship W2032223420A5064138186 @default.
• W2032223420 hasAuthorship W2032223420A5082413211 @default.
• W2032223420 hasAuthorship W2032223420A5083878777 @default.
• W2032223420 hasConcept C153911025 @default.
• W2032223420 hasConcept C179464577 @default.
• W2032223420 hasConcept C17991360 @default.
• W2032223420 hasConcept C181199279 @default.
• W2032223420 hasConcept C185592680 @default.
• W2032223420 hasConcept C203014093 @default.
• W2032223420 hasConcept C2776090121 @default.
• W2032223420 hasConcept C48349386 @default.
• W2032223420 hasConcept C538909803 @default.
• W2032223420 hasConcept C55493867 @default.
• W2032223420 hasConcept C79879829 @default.
• W2032223420 hasConcept C86803240 @default.
• W2032223420 hasConcept C8891405 @default.
• W2032223420 hasConcept C95444343 @default.
• W2032223420 hasConceptScore W2032223420C153911025 @default.
• W2032223420 hasConceptScore W2032223420C179464577 @default.
• W2032223420 hasConceptScore W2032223420C17991360 @default.
• W2032223420 hasConceptScore W2032223420C181199279 @default.
• W2032223420 hasConceptScore W2032223420C185592680 @default.
• W2032223420 hasConceptScore W2032223420C203014093 @default.
• W2032223420 hasConceptScore W2032223420C2776090121 @default.
• W2032223420 hasConceptScore W2032223420C48349386 @default.
• W2032223420 hasConceptScore W2032223420C538909803 @default.
• W2032223420 hasConceptScore W2032223420C55493867 @default.
• W2032223420 hasConceptScore W2032223420C79879829 @default.
• W2032223420 hasConceptScore W2032223420C86803240 @default.
• W2032223420 hasConceptScore W2032223420C8891405 @default.
• W2032223420 hasConceptScore W2032223420C95444343 @default.
• W2032223420 hasIssue "13" @default.
• W2032223420 hasLocation W20322234201 @default.
• W2032223420 hasLocation W20322234202 @default.
• W2032223420 hasOpenAccess W2032223420 @default.
• W2032223420 hasPrimaryLocation W20322234201 @default.

• next