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- W203223816 abstract "Background The aim of this study was to determine serum hepcidin concentrations and its associations with iron status in pregnant women and cord blood. 191 full-term pregnant women and newborns were studied. Blood from pregnant women was obtained within 24h of delivery, and venous cord blood shortly after birth. Serum hepcidin was measured by C-ELISA and compared to hematological and iron indices, including ferritin, TfR, %TSat, hsCRP, and EPO. Results Hepcidin in pregnant women was significantly lower than in the cord blood [GMC; 13.5 vs. 72.9 ng/mL, respectively]. Serum hepcidin was <5 ng/ml in 12% of pregnant women and in 2% of newborns. Hepcidin was significantly higher in vaginal and emergency section deliveries, compared to elective Cesarean. In pregnant women at term, 7–8% were iron deficient (Hb<110 g/L or %HYPOm >3.4%). Hepcidin was correlated with hsCRP and gestational weeks. 20% of newborns had Hb <145 g/L and 5% had TSat <30%, and were classified as iron deficient. Reference ranges for serum hepcidin at term pregnancy was 1.4 – 70.6 ng/mL (n=126; median 11.9 ng/mL) and for cord blood, 20.1 – 231.2 ng/mL (n=142; median 77.45 ng/mL). Conclusions Maternal hepcidin levels are suppressed at term facilitating iron transfer to the fetus, while newborn hepcidin levels are normal for the existing iron stores. Research funded by a grant to Kupio University Hospital and by Intrinsic LifeSciences." @default.
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- W203223816 date "2010-04-01" @default.
- W203223816 modified "2023-09-26" @default.
- W203223816 title "Circulating hepcidin at term pregnancy and in cord blood independently reflects maternal and fetal iron status" @default.
- W203223816 doi "https://doi.org/10.1096/fasebj.24.1_supplement.lb580" @default.
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