FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2032240459> ?p ?o ?g. }

• W2032240459 endingPage "99" @default.
• W2032240459 startingPage "99" @default.
• W2032240459 abstract "Genetic evidence linking lung cancer and COPD: a new perspective Robert P Young1,4, Raewyn J Hopkins1, Gregory D Gamble1, Carol Etzel2, Randa El-Zein2, James D Crapo31Department of Medicine and School of Biological Sciences, University of Auckland, Auckland, New Zealand; 2Department of Epidemiology, UT MD Anderson Cancer Center, Houston, TX, USA; 3National Jewish Health, Denver, CO, USA; 4Synergenz Biosciences Ltd, Auckland, New ZealandAbstract: Epidemiological studies indicate that tobacco smoke exposure accounts for nearly 90% of cases of chronic obstructive pulmonary disease (COPD) and lung cancer. However, genetic factors may explain why 10%–30% of smokers develop these complications. This perspective reviews the evidence suggesting that COPD is closely linked to susceptibility to lung cancer and outlines the potential relevance of this observation. Epidemiological studies show that COPD is the single most important risk factor for lung cancer among smokers and predates lung cancer in up to 80% of cases. Genome-wide association studies of lung cancer, lung function, and COPD have identified a number of overlapping “susceptibility” loci. With stringent phenotyping, it has recently been shown that several of these overlapping loci are independently associated with both COPD and lung cancer. These loci implicate genes underlying pulmonary inflammation and apoptotic processes mediated by the bronchial epithelium, and link COPD with lung cancer at a molecular genetic level. It is currently possible to derive risk models for lung cancer that incorporate lung cancer-specific genetic variants, recently identified “COPD-related” genetic variants, and clinical variables. Early studies suggest that single nucleotide polymorphism-based risk stratification of smokers might help better target novel prevention and early diagnostic strategies in lung cancer.Keywords: lung cancer, chronic obstructive pulmonary disease, association study, single nucleotide polymorphism, risk model" @default.
• W2032240459 created "2016-06-24" @default.
• W2032240459 creator A5004622383 @default.
• W2032240459 creator A5032885485 @default.
• W2032240459 creator A5050358373 @default.
• W2032240459 creator A5066776956 @default.
• W2032240459 creator A5072296816 @default.
• W2032240459 creator A5089805011 @default.
• W2032240459 date "2011-07-01" @default.
• W2032240459 modified "2023-10-17" @default.
• W2032240459 title "Genetic evidence linking lung cancer and COPD: a new perspective" @default.
• W2032240459 cites W1588925236 @default.
• W2032240459 cites W1885319379 @default.
• W2032240459 cites W1963612032 @default.
• W2032240459 cites W1964185212 @default.
• W2032240459 cites W1964478846 @default.
• W2032240459 cites W1970548926 @default.
• W2032240459 cites W1971000546 @default.
• W2032240459 cites W1971501057 @default.
• W2032240459 cites W1972020976 @default.
• W2032240459 cites W1974326568 @default.
• W2032240459 cites W1976389681 @default.
• W2032240459 cites W1977273234 @default.
• W2032240459 cites W1979581505 @default.
• W2032240459 cites W1981378561 @default.
• W2032240459 cites W1986672886 @default.
• W2032240459 cites W1995900625 @default.
• W2032240459 cites W2002818848 @default.
• W2032240459 cites W2006720016 @default.
• W2032240459 cites W2021085462 @default.
• W2032240459 cites W2026663933 @default.
• W2032240459 cites W2032580948 @default.
• W2032240459 cites W2033884499 @default.
• W2032240459 cites W2035261868 @default.
• W2032240459 cites W2037247639 @default.
• W2032240459 cites W2045869274 @default.
• W2032240459 cites W2048241180 @default.
• W2032240459 cites W2055296003 @default.
• W2032240459 cites W2063937704 @default.
• W2032240459 cites W2064786372 @default.
• W2032240459 cites W2066422496 @default.
• W2032240459 cites W2075040668 @default.
• W2032240459 cites W2075747141 @default.
• W2032240459 cites W2077030176 @default.
• W2032240459 cites W2082536587 @default.
• W2032240459 cites W2089415609 @default.
• W2032240459 cites W2089703171 @default.
• W2032240459 cites W2090092693 @default.
• W2032240459 cites W2093921175 @default.
• W2032240459 cites W2100950730 @default.
• W2032240459 cites W2101359494 @default.
• W2032240459 cites W2101813837 @default.
• W2032240459 cites W2103809903 @default.
• W2032240459 cites W2103821820 @default.
• W2032240459 cites W2107766358 @default.
• W2032240459 cites W2111344085 @default.
• W2032240459 cites W2112495658 @default.
• W2032240459 cites W2113217101 @default.
• W2032240459 cites W2115485344 @default.
• W2032240459 cites W2117079188 @default.
• W2032240459 cites W2117240972 @default.
• W2032240459 cites W2118082971 @default.
• W2032240459 cites W2118510964 @default.
• W2032240459 cites W2119678176 @default.
• W2032240459 cites W2119729352 @default.
• W2032240459 cites W2120240963 @default.
• W2032240459 cites W2120902800 @default.
• W2032240459 cites W2123600689 @default.
• W2032240459 cites W2125063678 @default.
• W2032240459 cites W2128180660 @default.
• W2032240459 cites W2128401861 @default.
• W2032240459 cites W2132297922 @default.
• W2032240459 cites W2132869277 @default.
• W2032240459 cites W2133461233 @default.
• W2032240459 cites W2133910607 @default.
• W2032240459 cites W2137397912 @default.
• W2032240459 cites W2137899444 @default.
• W2032240459 cites W2139658078 @default.
• W2032240459 cites W2139697423 @default.
• W2032240459 cites W2146533975 @default.
• W2032240459 cites W2148263031 @default.
• W2032240459 cites W2150472441 @default.
• W2032240459 cites W2154208846 @default.
• W2032240459 cites W2154589460 @default.
• W2032240459 cites W2156670823 @default.
• W2032240459 cites W2161352015 @default.
• W2032240459 cites W2163496983 @default.
• W2032240459 cites W2166406579 @default.
• W2032240459 cites W2167405133 @default.
• W2032240459 cites W2167612351 @default.
• W2032240459 cites W2169237347 @default.
• W2032240459 cites W2169973391 @default.
• W2032240459 cites W2314647810 @default.
• W2032240459 cites W2327951273 @default.
• W2032240459 cites W2332123422 @default.
• W2032240459 doi "https://doi.org/10.2147/tacg.s20083" @default.
• W2032240459 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3681182" @default.
• W2032240459 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23776371" @default.

• next