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- W2032240634 abstract "Tryptophan (Trp) is abundant in membrane proteins, preferentially residing near the lipid–water interface where it is thought to play a significant anchoring role. Using a total of 3 μs of molecular dynamics simulations for a library of hydrophobic WALP-like peptides, a long poly-Leu α-helix, and the methyl-indole analog, we explore the thermodynamics of the Trp movement in membranes that governs the stability and orientation of transmembrane protein segments. We examine the dominant hydrogen-bonding interactions between the Trp and lipid carbonyl and phosphate moieties, cation–π interactions to lipid choline moieties, and elucidate the contributions to the thermodynamics that serve to localize the Trp, by ~ 4 kcal/mol, near the membrane glycerol backbone region. We show a striking similarity between the free energy to move an isolated Trp side chain to that found from a wide range of WALP peptides, suggesting that the location of this side chain is nearly independent of the host transmembrane segment. Our calculations provide quantitative measures that explain Trp's role as a modulator of responses to hydrophobic mismatch, providing a deeper understanding of how lipid composition may control a range of membrane active peptides and proteins." @default.
- W2032240634 created "2016-06-24" @default.
- W2032240634 creator A5008269794 @default.
- W2032240634 creator A5068923509 @default.
- W2032240634 date "2013-02-01" @default.
- W2032240634 modified "2023-10-02" @default.
- W2032240634 title "The role of tryptophan side chains in membrane protein anchoring and hydrophobic mismatch" @default.
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- W2032240634 doi "https://doi.org/10.1016/j.bbamem.2012.09.009" @default.
- W2032240634 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/22989724" @default.
- W2032240634 hasPublicationYear "2013" @default.
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