FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2032243072> ?p ?o ?g. }

• W2032243072 endingPage "e12089" @default.
• W2032243072 startingPage "e12089" @default.
• W2032243072 abstract "Background Bacillus anthracis, Francisella tularensis, and Yersinia pestis are bacterial pathogens that can cause anthrax, lethal acute pneumonic disease, and bubonic plague, respectively, and are listed as NIAID Category A priority pathogens for possible use as biological weapons. However, the interactions between human proteins and proteins in these bacteria remain poorly characterized leading to an incomplete understanding of their pathogenesis and mechanisms of immune evasion. Methodology In this study, we used a high-throughput yeast two-hybrid assay to identify physical interactions between human proteins and proteins from each of these three pathogens. From more than 250,000 screens performed, we identified 3,073 human-B. anthracis, 1,383 human-F. tularensis, and 4,059 human-Y. pestis protein-protein interactions including interactions involving 304 B. anthracis, 52 F. tularensis, and 330 Y. pestis proteins that are uncharacterized. Computational analysis revealed that pathogen proteins preferentially interact with human proteins that are hubs and bottlenecks in the human PPI network. In addition, we computed modules of human-pathogen PPIs that are conserved amongst the three networks. Functionally, such conserved modules reveal commonalities between how the different pathogens interact with crucial host pathways involved in inflammation and immunity. Significance These data constitute the first extensive protein interaction networks constructed for bacterial pathogens and their human hosts. This study provides novel insights into host-pathogen interactions." @default.
• W2032243072 created "2016-06-24" @default.
• W2032243072 creator A5003895515 @default.
• W2032243072 creator A5011856854 @default.
• W2032243072 creator A5016799890 @default.
• W2032243072 creator A5050693551 @default.
• W2032243072 creator A5058609337 @default.
• W2032243072 creator A5058888863 @default.
• W2032243072 creator A5073142937 @default.
• W2032243072 creator A5078405095 @default.
• W2032243072 date "2010-08-09" @default.
• W2032243072 modified "2023-10-14" @default.
• W2032243072 title "The Human-Bacterial Pathogen Protein Interaction Networks of Bacillus anthracis, Francisella tularensis, and Yersinia pestis" @default.
• W2032243072 cites W1544009106 @default.
• W2032243072 cites W1547879048 @default.
• W2032243072 cites W1555821747 @default.
• W2032243072 cites W1656916634 @default.
• W2032243072 cites W1667747872 @default.
• W2032243072 cites W1748306974 @default.
• W2032243072 cites W1769519545 @default.
• W2032243072 cites W1971937094 @default.
• W2032243072 cites W1974906719 @default.
• W2032243072 cites W1982428412 @default.
• W2032243072 cites W1994803330 @default.
• W2032243072 cites W1998856404 @default.
• W2032243072 cites W2007119893 @default.
• W2032243072 cites W2008856488 @default.
• W2032243072 cites W2031407766 @default.
• W2032243072 cites W2042168393 @default.
• W2032243072 cites W2042984464 @default.
• W2032243072 cites W2071482027 @default.
• W2032243072 cites W2075964433 @default.
• W2032243072 cites W2080241101 @default.
• W2032243072 cites W2088422296 @default.
• W2032243072 cites W2101181377 @default.
• W2032243072 cites W2102155970 @default.
• W2032243072 cites W2103017472 @default.
• W2032243072 cites W2115916446 @default.
• W2032243072 cites W2128036243 @default.
• W2032243072 cites W2130410032 @default.
• W2032243072 cites W2130687290 @default.
• W2032243072 cites W2131858707 @default.
• W2032243072 cites W2136316164 @default.
• W2032243072 cites W2136646641 @default.
• W2032243072 cites W2138368629 @default.
• W2032243072 cites W2145638464 @default.
• W2032243072 cites W2147633054 @default.
• W2032243072 cites W2147714160 @default.
• W2032243072 cites W2150318080 @default.
• W2032243072 cites W2150934340 @default.
• W2032243072 cites W2155723007 @default.
• W2032243072 cites W2158700061 @default.
• W2032243072 cites W2164813401 @default.
• W2032243072 cites W2167188257 @default.
• W2032243072 cites W2171081680 @default.
• W2032243072 cites W2171707538 @default.
• W2032243072 cites W2916288174 @default.
• W2032243072 cites W4313324524 @default.
• W2032243072 doi "https://doi.org/10.1371/journal.pone.0012089" @default.
• W2032243072 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2918508" @default.
• W2032243072 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/20711500" @default.
• W2032243072 hasPublicationYear "2010" @default.
• W2032243072 type Work @default.
• W2032243072 sameAs 2032243072 @default.
• W2032243072 citedByCount "126" @default.
• W2032243072 countsByYear W20322430722012 @default.
• W2032243072 countsByYear W20322430722013 @default.
• W2032243072 countsByYear W20322430722014 @default.
• W2032243072 countsByYear W20322430722015 @default.
• W2032243072 countsByYear W20322430722016 @default.
• W2032243072 countsByYear W20322430722017 @default.
• W2032243072 countsByYear W20322430722018 @default.
• W2032243072 countsByYear W20322430722019 @default.
• W2032243072 countsByYear W20322430722020 @default.
• W2032243072 countsByYear W20322430722021 @default.
• W2032243072 countsByYear W20322430722022 @default.
• W2032243072 countsByYear W20322430722023 @default.
• W2032243072 crossrefType "journal-article" @default.
• W2032243072 hasAuthorship W2032243072A5003895515 @default.
• W2032243072 hasAuthorship W2032243072A5011856854 @default.
• W2032243072 hasAuthorship W2032243072A5016799890 @default.
• W2032243072 hasAuthorship W2032243072A5050693551 @default.
• W2032243072 hasAuthorship W2032243072A5058609337 @default.
• W2032243072 hasAuthorship W2032243072A5058888863 @default.
• W2032243072 hasAuthorship W2032243072A5073142937 @default.
• W2032243072 hasAuthorship W2032243072A5078405095 @default.
• W2032243072 hasBestOaLocation W20322430721 @default.
• W2032243072 hasConcept C104317684 @default.
• W2032243072 hasConcept C159047783 @default.
• W2032243072 hasConcept C24527192 @default.
• W2032243072 hasConcept C2776460866 @default.
• W2032243072 hasConcept C2778222588 @default.
• W2032243072 hasConcept C2780239966 @default.
• W2032243072 hasConcept C2780467176 @default.
• W2032243072 hasConcept C2780796267 @default.
• W2032243072 hasConcept C523546767 @default.
• W2032243072 hasConcept C54355233 @default.
• W2032243072 hasConcept C60987743 @default.

• next