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- W2032253197 abstract "A significant fraction of carbon monoxide (CO) poisoning victims die before discovery or rescue. Although survivors usually show normal or elevated blood glucose, data from an animal model now suggest an association between low blood glucose and death during CO poisoning. Hypoglycemia observed during the later stages of CO poisoning in the rat was intensified by increased CO concentration (2,400 ppm, 2,700 ppm, 3,000 ppm) and by the infusion or injection of normal saline, both in survivors and in nonsurvivors, but glucose lowering was especially marked in the latter group. Mortality rate was similarly increased by these two conditions. Based on the change in blood glucose concentration early in CO poisoning, it should be possible to identify survivors and nonsurvivors. Survivors showed a hyperglycemic “rebound” 2 hours after CO. Nonsurvivors tended to maintain a higher body temperature and heart rate, and a relatively smaller decrease in blood pressure during CO exposure, presumably due to a higher metabolic rate. This is possibly a major factor responsible for the rapid lowering of blood glucose concentration. Concurrent administration of ethanol to two to four times the legal intoxication blood level in humans did not alter the severity of CO-induced hypoglycemia in either survivors or nonsurvivors, but did increase survival and exacerbated “rebound” hyperglycemia in survivors. Blood ethanol concentration is elevated by CO poisoning in a dose-dependent manner. The likely mechanisms) underlying CO-induced hypoglycemia, the complicating effect of concurrent ETOH intoxication, and their clinical relevance are discussed." @default.
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- W2032253197 date "1990-09-01" @default.
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- W2032253197 title "Development of hypoglycemia is associated with death during carbon monoxide poisoning" @default.
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- W2032253197 doi "https://doi.org/10.1016/0883-9441(90)90038-b" @default.
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