FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2032253382> ?p ?o ?g. }

• W2032253382 endingPage "255" @default.
• W2032253382 startingPage "248" @default.
• W2032253382 abstract "Chronic renal failure is associated with abnormalities of skeletal muscle that include reduction in size, fibrosis, protein depletion, and functional disorders. These disorders may be caused by several factors, including protein-calorie malnutrition, acidemia, and superimposed illnesses. However, animal research suggests that these abnormalities may occur with chronic renal failure per se in the absence of the above complications. Insulin-like growth factor 1 (IGF-1) is an anabolic hormone that, in skeletal muscle, stimulates intracellular amino acid and glucose transport and protein synthesis, suppresses protein degradation, and causes hypertrophy. In chronic renal failure, there is evidence for inhibition of the actions of IGF-1. Studies in humans with chronic renal failure given a subcutaneous injection of recombinant human IGF-1 (rhIGF-1) indicate that the rhIGF-1 induced acute suppression of plasma amino acids, insulin, and C peptide is impaired. In skeletal muscle of rats with chronic renal failure, we observed reduced IGF-1 and IGF-1 mRNA levels, resistance to the rhIGF-1-induced suppression of protein degradation, and stimulation of protein synthesis, increased IGF-1 receptor mRNA and IGF-1 receptor number and impaired receptor tyrosine kinase activity. These findings suggest that in skeletal muscle in chronic renal failure there are several abnormalities in the physiology of IGF-1 and the sensitivity to IGF-1. It is possible that these alterations contribute to the disorders of skeletal muscle structure and function in chronic renal failure. Notwithstanding these abnormalities, repeated subcutaneous injections of rhIGF-1 in malnourished patients undergoing continuous ambulatory peritoneal dialysis led to strongly positive nitrogen balance that was sustained for the 20 days of study.(ABSTRACT TRUNCATED AT 250 WORDS)" @default.
• W2032253382 created "2016-06-24" @default.
• W2032253382 creator A5003427538 @default.
• W2032253382 creator A5045416081 @default.
• W2032253382 creator A5050491175 @default.
• W2032253382 date "1995-07-01" @default.
• W2032253382 modified "2023-10-10" @default.
• W2032253382 title "Altered physiology and action of insulin-like growth factor 1 in skeletal muscle in chronic renal failure" @default.
• W2032253382 cites W1177541621 @default.
• W2032253382 cites W1508807714 @default.
• W2032253382 cites W1516064383 @default.
• W2032253382 cites W1626137351 @default.
• W2032253382 cites W1650022899 @default.
• W2032253382 cites W1868177001 @default.
• W2032253382 cites W1947605156 @default.
• W2032253382 cites W1963523577 @default.
• W2032253382 cites W1963584943 @default.
• W2032253382 cites W1967726314 @default.
• W2032253382 cites W1969208588 @default.
• W2032253382 cites W1971581415 @default.
• W2032253382 cites W1976626618 @default.
• W2032253382 cites W1977000145 @default.
• W2032253382 cites W1980822545 @default.
• W2032253382 cites W1983221409 @default.
• W2032253382 cites W1993124792 @default.
• W2032253382 cites W1993200234 @default.
• W2032253382 cites W1995566255 @default.
• W2032253382 cites W2000293700 @default.
• W2032253382 cites W2004475446 @default.
• W2032253382 cites W2005560754 @default.
• W2032253382 cites W2005928583 @default.
• W2032253382 cites W2009530744 @default.
• W2032253382 cites W2009985073 @default.
• W2032253382 cites W2014792180 @default.
• W2032253382 cites W2028319677 @default.
• W2032253382 cites W2028527312 @default.
• W2032253382 cites W2029040016 @default.
• W2032253382 cites W2030487871 @default.
• W2032253382 cites W2037887467 @default.
• W2032253382 cites W2038833653 @default.
• W2032253382 cites W2039078115 @default.
• W2032253382 cites W2043169238 @default.
• W2032253382 cites W2050907446 @default.
• W2032253382 cites W2051100223 @default.
• W2032253382 cites W2053002773 @default.
• W2032253382 cites W2054800937 @default.
• W2032253382 cites W2059291167 @default.
• W2032253382 cites W2066114232 @default.
• W2032253382 cites W2069436261 @default.
• W2032253382 cites W2071377172 @default.
• W2032253382 cites W2078940941 @default.
• W2032253382 cites W2081096579 @default.
• W2032253382 cites W2082355794 @default.
• W2032253382 cites W2087511626 @default.
• W2032253382 cites W2088061978 @default.
• W2032253382 cites W2088618511 @default.
• W2032253382 cites W2088670766 @default.
• W2032253382 cites W2096523173 @default.
• W2032253382 cites W2106867463 @default.
• W2032253382 cites W2137915193 @default.
• W2032253382 cites W2144545567 @default.
• W2032253382 cites W2146854188 @default.
• W2032253382 cites W2148305832 @default.
• W2032253382 cites W2151905809 @default.
• W2032253382 cites W2165630567 @default.
• W2032253382 cites W2409749685 @default.
• W2032253382 cites W4241709163 @default.
• W2032253382 cites W4377298280 @default.
• W2032253382 doi "https://doi.org/10.1016/0272-6386(95)90180-9" @default.
• W2032253382 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/7611259" @default.
• W2032253382 hasPublicationYear "1995" @default.
• W2032253382 type Work @default.
• W2032253382 sameAs 2032253382 @default.
• W2032253382 citedByCount "13" @default.
• W2032253382 countsByYear W20322533822014 @default.
• W2032253382 crossrefType "journal-article" @default.
• W2032253382 hasAuthorship W2032253382A5003427538 @default.
• W2032253382 hasAuthorship W2032253382A5045416081 @default.
• W2032253382 hasAuthorship W2032253382A5050491175 @default.
• W2032253382 hasConcept C1008401 @default.
• W2032253382 hasConcept C126322002 @default.
• W2032253382 hasConcept C134018914 @default.
• W2032253382 hasConcept C167414201 @default.
• W2032253382 hasConcept C170493617 @default.
• W2032253382 hasConcept C2775960820 @default.
• W2032253382 hasConcept C2778653478 @default.
• W2032253382 hasConcept C2779959927 @default.
• W2032253382 hasConcept C2779978075 @default.
• W2032253382 hasConcept C2780689927 @default.
• W2032253382 hasConcept C2909406889 @default.
• W2032253382 hasConcept C2992195973 @default.
• W2032253382 hasConcept C71924100 @default.
• W2032253382 hasConcept C86803240 @default.
• W2032253382 hasConcept C95444343 @default.
• W2032253382 hasConceptScore W2032253382C1008401 @default.
• W2032253382 hasConceptScore W2032253382C126322002 @default.
• W2032253382 hasConceptScore W2032253382C134018914 @default.
• W2032253382 hasConceptScore W2032253382C167414201 @default.

• next