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- W2032258614 abstract "Natural killer T (NKT) cells are a distinct lymphocyte lineage that regulates immune responses. During their development in the thymus, immature uncommitted double-positive CD4+CD8+ thymocytes that rearrange the semi-invariant T-cell receptor found on mature NKT cells are positively selected by the non-classical MHC class I molecule CD1d, which is expressed at the surface of cortical thymocytes. At this stage, the positively selected cells branch off from the conventional T-cell developmental program and start to acquire activated and/or memory markers and several 'bona fide' NK cell attributes. Recent work has started to reveal the specific developmental requirements for this divergent pathway of differentiation. These include several signal transduction molecules, transcription factors and cytokines, including T-bet, members of the NF-kappaB family, Fyn and IL-15." @default.
- W2032258614 created "2016-06-24" @default.
- W2032258614 creator A5036961569 @default.
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- W2032258614 date "2005-04-01" @default.
- W2032258614 modified "2023-09-26" @default.
- W2032258614 title "Developmental program of mouse Vα14i NKT cells" @default.
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- W2032258614 doi "https://doi.org/10.1016/j.coi.2005.01.002" @default.
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