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• W2032266655 abstract "Both alpha beta and gamma delta T-cell populations and natural killer (NK) cells include cytotoxic, interferon (IFN)-gamma-producing lymphocytes that actively respond to viral infections. We show here that all three populations can provide natural resistance to viruses very early in infection and describe how the T-cell populations are modulated to provide this function. gamma delta T cells were shown to play a role in controlling vaccinia virus (VV) infections, as VV grew to much higher titers in gamma delta T-cell knockout mice than in normal mice 3-4 days post-infection. Our studies of the alpha beta T-cell responses to viruses revealed an interactive network of T cells that is modulated substantially during systemic infections. There is an induction phase associated with a massive virus-specific CD8 T-cell response, an apoptosis phase during which the T cells become sensitized to activation-induced cell death (AICD), a silencing phase, during which the T-cell number and activation state is reduced, and, finally, a memory phase associated with the very stable preservation of virus-specific memory cytotoxic T-lymphocyte precursors (pCTL). Infection of mice immune to one virus with a heterologous virus leads to a selective expansion of memory CTL cross-reacting between the two viruses, but, after homeostasis is again established, there is a quantitative reduction and qualitative alteration of memory to the first virus. Our results suggest that memory alpha beta T cells cross-reactive between heterologous viruses mediate both immunopathology and protective immunity at early stages of the second virus infection. Thus, memory alpha beta T cells can, like gamma delta T cells and NK cells, provide natural immunity to viral infections." @default.
• W2032266655 created "2016-06-24" @default.
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• W2032266655 creator A5023677057 @default.
• W2032266655 creator A5034784009 @default.
• W2032266655 creator A5045980065 @default.
• W2032266655 date "1997-10-01" @default.
• W2032266655 modified "2023-10-02" @default.
• W2032266655 title "alphabeta and gammadelta T-cell networks and their roles in natural resistance to viral infections" @default.
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• W2032266655 doi "https://doi.org/10.1111/j.1600-065x.1997.tb01008.x" @default.
• W2032266655 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/9416504" @default.
• W2032266655 hasPublicationYear "1997" @default.
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