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• W2032272012 abstract "Ten inbred strains of mice were fed an atherogenic diet containing 1.25% cholesterol, 0.5% cholic acid and 15% fat. The strains were examined for plasma cholesterol and triglyceride levels and for formation of lipid-containing lesions in the aortic wall. The strains differed considerably in the frequency of lesion formation after 14 weeks on the atherogenic diet with a range of 0–1.8 lesions/mouse. The order of susceptibility to lesion formation from the least susceptible to the most susceptible was BALB/cJ, C3H/J, A/J, SWR/J, NZB/J, <129/J, AKR/J, DBA/2J, <C57L/J <C57BL/6J. Total plasma cholesterol after 5 weeks on the diet varied from 131 mg/dl to 328 mg/dl among strains; however, there was little correlation between total cholesterol levels and susceptibility to lesion formation (r = 0.29). Plasma triglycerides after 5 weeks on the diet varied less than cholesterol with a range of 137–220 mg/dl. An analysis of the genetic differences among inbred strains of mice might provide useful insights into lipid metabolism and the development of atherosclerosis." @default.
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• W2032272012 date "1985-10-01" @default.
• W2032272012 modified "2023-10-16" @default.
• W2032272012 title "Variation in susceptibility to atherosclerosis among inbred strains of mice" @default.
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• W2032272012 doi "https://doi.org/10.1016/0021-9150(85)90138-8" @default.
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