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- W2032273242 abstract "Treatment of rabbit brain membranes of the DHP binding sites of L-type Ca2+ channel with lysine-specific reagent resulted in a time- and concentration-dependent loss of [3H]nitrendipine binding activity. Following exposure to the maximum concentration of PLP (100 mM), [3H]nitrendipine binding was inhibited by up to 96.5%. Scatchard analysis of the binding data indicated that treatment with PLP resulted in a loss of [3H]nitrendipine binding sites with no effect on binding affinity. Considerable protection against PLP inactivation was obtained by nifedipine. These results indicate that lysine residue plays a critical role in maintaining the DHP-binding sites in a conformation capable of ligand binding." @default.
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- W2032273242 date "1998-04-01" @default.
- W2032273242 modified "2023-09-23" @default.
- W2032273242 title "Chemical modification of the dihydropyridines binding sites by lysine reagent, pyridoxal 5′-phosphate" @default.
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- W2032273242 doi "https://doi.org/10.1016/s0197-0186(97)00100-9" @default.
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