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- W2032295890 abstract "A simple linear approach to estimate the aqueous pKa of compounds sparingly soluble in water, mainly drugs, from solely one pKa value determined in any methanol/water mixture is evaluated. The parameters (slope and intercept) of the linear relationships are related to the solvent composition and can be easily calculated according to the acidic or basic functional group of the compound. The method has been tested using the available literature data for phenols, aliphatic carboxylic acids, benzoic acid derivatives, both ortho and non-ortho substituted, amines and imidazole derivatives. The study involves the whole range of solvent composition and about one hundred compounds which show a wide variety of aqueous pKa, from 1.3 to 12.4. The differences between calculated and previously published aqueous pKa values are less of 0.2 pK units. Consistent values are obtained whatever the composition of methanol/water mixture employed in the experimental measurements. The results support the usefulness of the tested method as a very simple approach to get reliable aqueous pKa values for sparingly soluble drugs." @default.
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- W2032295890 date "2005-09-01" @default.
- W2032295890 modified "2023-09-25" @default.
- W2032295890 title "Critical validation of a new simpler approach to estimate aqueous pKa of drugs sparingly soluble in water" @default.
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- W2032295890 doi "https://doi.org/10.1016/j.aca.2005.06.058" @default.
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