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- W2032296237 abstract "Induction of foci of atypical liver cells (ATPase-deficient islands, which previously have been shown to serve as tumour cell precursor) by a single dose of diethyl-nitrosamine in partially hepatectomized rats showed direct proportionality between number of islands and dose up to 30 mg DENA/kg, pointing to a one-hit mechanism of induction. The curve relating number of islands to dose levelled off at ≧ 50 mg/kg, and this was interpreted as resulting mainly from the toxic action of the carcinogen. Island size (the number of cells per island) was independent of dose up to 30 mg DENA/kg, but progressively increased in the higher dose range. Increased proliferation of island cells was attributed to the regenerative stimulus stemming from the toxic effect of the carcinogen at the higher doses. Analogous findings resulted from the measurement of island induction in the livers of intact rats receiving 0·9–14 mg DENA/kg daily for 4 weeks. A single dose of ≧ 50 mg DENA/kg produced hepatocellular tumours in the partially hepatectomized rat. Liver tumour formation in this system is discussed and the significance of cell proliferation (DNA synthesis) for the various phases of the hepatocarcinogenic process is stressed." @default.
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- W2032296237 title "Kinetics of induction and growth of precancerous liver-cell foci, and liver tumour formation by diethylnitrosamine in the rat" @default.
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- W2032296237 doi "https://doi.org/10.1016/0014-2964(75)90042-0" @default.
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