Matches in SemOpenAlex for { <https://semopenalex.org/work/W2032303940> ?p ?o ?g. }
Showing items 1 to 88 of
88
with 100 items per page.
- W2032303940 endingPage "362" @default.
- W2032303940 startingPage "354" @default.
- W2032303940 abstract "The effects of various inhibitors on the activity of calcium-independent and calcium-dependent phosphodiesterases from rat cerebral cortex were examined. While the agents varied greatly in their relative potency, each was found to be approximately equipotent in inhibiting the calcium-dependent hydrolysis of either cyclic AMP or cyclic GMP. In contrast, the inhibitors displayed a marked substrate specificity for the calcium-independent enzyme with ratios of IC50 values for inhibition of cyclic GMP hydrolysis when compared to cyclic AMP hydrolysis in decreasing order being: ZK 62711 (⪢ 100) > Ro 20–1724 (⪢>25) papaverine (13) > 7-benzyl IBMX (4) > quercetin and kaempferol (2). The differential selectivity of the inhibitors for the two enzymes was most pronounced for ZK 62711 and Ro 20–1724 which were at least 25–100-times more potent in inhibiting the calcium-independent hydrolysis of cyclic AMP when compared to the calcium-dependent hydrolysis of cyclic AMP. In contrast, 7-benzyl IBMX, kaempferol and quercetin were 8–100-times more effective as inhibitors of cycluc GMP hydrolysis by the calcium-dependent phosphodiesterase while 7-benzyl IBMX and trimazosin displayed a similar enzyme selectivity using cyclic AMP as substrate. With the exception of papaverine, all agents were competitive inhibitors of the calcium-dependent phosphodiesterase. The type of inhibition observed with the calcium-independent enzyme was dependent on the substrate employed. The specificity of potassium ions in inhibiting the activity of the calcium-dependent phosphodiesterase and deoxycyclic AMP in inhibiting the calcium-independent enzyme was found to provide a convenient means to assess the effects of agents on these activities in crude extracts of cerebral cortex." @default.
- W2032303940 created "2016-06-24" @default.
- W2032303940 creator A5052565673 @default.
- W2032303940 date "1984-03-01" @default.
- W2032303940 modified "2023-10-17" @default.
- W2032303940 title "Assessment of selective inhibition of rat cerebral cortical calcium-independent and calcium-dependent phosphodiesterases in crude extracts using deoxycyclic AMP and potassium ions" @default.
- W2032303940 cites W1505846226 @default.
- W2032303940 cites W1559386011 @default.
- W2032303940 cites W1574870728 @default.
- W2032303940 cites W1587089734 @default.
- W2032303940 cites W1589645365 @default.
- W2032303940 cites W168583190 @default.
- W2032303940 cites W177479641 @default.
- W2032303940 cites W1775749144 @default.
- W2032303940 cites W1974860814 @default.
- W2032303940 cites W1975553909 @default.
- W2032303940 cites W1991233650 @default.
- W2032303940 cites W1992948033 @default.
- W2032303940 cites W2008266731 @default.
- W2032303940 cites W2032198513 @default.
- W2032303940 cites W2033127447 @default.
- W2032303940 cites W2039198752 @default.
- W2032303940 cites W2048771536 @default.
- W2032303940 cites W2050771781 @default.
- W2032303940 cites W2055702554 @default.
- W2032303940 cites W2056987277 @default.
- W2032303940 cites W2064849802 @default.
- W2032303940 cites W2067443500 @default.
- W2032303940 cites W2082190079 @default.
- W2032303940 cites W2090527176 @default.
- W2032303940 cites W2091436682 @default.
- W2032303940 cites W2093822310 @default.
- W2032303940 cites W297286336 @default.
- W2032303940 cites W90454921 @default.
- W2032303940 doi "https://doi.org/10.1016/0304-4165(84)90257-5" @default.
- W2032303940 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/6320906" @default.
- W2032303940 hasPublicationYear "1984" @default.
- W2032303940 type Work @default.
- W2032303940 sameAs 2032303940 @default.
- W2032303940 citedByCount "74" @default.
- W2032303940 countsByYear W20323039402013 @default.
- W2032303940 countsByYear W20323039402017 @default.
- W2032303940 countsByYear W20323039402022 @default.
- W2032303940 countsByYear W20323039402023 @default.
- W2032303940 crossrefType "journal-article" @default.
- W2032303940 hasAuthorship W2032303940A5052565673 @default.
- W2032303940 hasConcept C178790620 @default.
- W2032303940 hasConcept C181199279 @default.
- W2032303940 hasConcept C185592680 @default.
- W2032303940 hasConcept C202751555 @default.
- W2032303940 hasConcept C2779276759 @default.
- W2032303940 hasConcept C2780215583 @default.
- W2032303940 hasConcept C2781298581 @default.
- W2032303940 hasConcept C519063684 @default.
- W2032303940 hasConcept C55493867 @default.
- W2032303940 hasConcept C62826618 @default.
- W2032303940 hasConceptScore W2032303940C178790620 @default.
- W2032303940 hasConceptScore W2032303940C181199279 @default.
- W2032303940 hasConceptScore W2032303940C185592680 @default.
- W2032303940 hasConceptScore W2032303940C202751555 @default.
- W2032303940 hasConceptScore W2032303940C2779276759 @default.
- W2032303940 hasConceptScore W2032303940C2780215583 @default.
- W2032303940 hasConceptScore W2032303940C2781298581 @default.
- W2032303940 hasConceptScore W2032303940C519063684 @default.
- W2032303940 hasConceptScore W2032303940C55493867 @default.
- W2032303940 hasConceptScore W2032303940C62826618 @default.
- W2032303940 hasIssue "3" @default.
- W2032303940 hasLocation W20323039401 @default.
- W2032303940 hasLocation W20323039402 @default.
- W2032303940 hasOpenAccess W2032303940 @default.
- W2032303940 hasPrimaryLocation W20323039401 @default.
- W2032303940 hasRelatedWork W1995265880 @default.
- W2032303940 hasRelatedWork W1996634388 @default.
- W2032303940 hasRelatedWork W2008845239 @default.
- W2032303940 hasRelatedWork W2036246796 @default.
- W2032303940 hasRelatedWork W2041277795 @default.
- W2032303940 hasRelatedWork W2052481124 @default.
- W2032303940 hasRelatedWork W2088495869 @default.
- W2032303940 hasRelatedWork W2089664452 @default.
- W2032303940 hasRelatedWork W2185576251 @default.
- W2032303940 hasRelatedWork W2419429268 @default.
- W2032303940 hasVolume "797" @default.
- W2032303940 isParatext "false" @default.
- W2032303940 isRetracted "false" @default.
- W2032303940 magId "2032303940" @default.
- W2032303940 workType "article" @default.