Matches in SemOpenAlex for { <https://semopenalex.org/work/W2032321569> ?p ?o ?g. }
- W2032321569 endingPage "158" @default.
- W2032321569 startingPage "150" @default.
- W2032321569 abstract "Parkinsons disease (PD) is a neurological disorder characterized by the progressive impairment of motor skills in patients. Growing evidence suggests that abnormal redox-active metal accumulation, caused by dysregulation, plays a central role in the neuropathology of PD. Redox-active metals (e.g. Fe and Cu) catalyze essential reactions for brain function. However, these metals can also participate in the generation of highly toxic free radicals that can cause oxidative damage to cells and ultimately lead to the death of dopamine-containing neurons. The emergence of redox-active metals as key players in the pathogenesis of PD strongly suggests that metal-chelators could be beneficial in the treatment of this condition. This mini-review summarizes major recent developments on natural, synthetic iron chelating compounds and hydrogen peroxide-triggered prochelators as potential candidates for PD treatment. Keywords: Parkinson's disease, iron, chelator, polyphenol, fenton reaction, free radicals" @default.
- W2032321569 created "2016-06-24" @default.
- W2032321569 creator A5020451831 @default.
- W2032321569 creator A5044976724 @default.
- W2032321569 creator A5059678053 @default.
- W2032321569 date "2008-10-01" @default.
- W2032321569 modified "2023-09-25" @default.
- W2032321569 title "Iron Chelators as Potential Therapeutic Agents for Parkinsons Disease" @default.
- W2032321569 cites W112686769 @default.
- W2032321569 cites W11984896 @default.
- W2032321569 cites W1536657536 @default.
- W2032321569 cites W1862214936 @default.
- W2032321569 cites W1927697688 @default.
- W2032321569 cites W1963841078 @default.
- W2032321569 cites W1969609724 @default.
- W2032321569 cites W1971389338 @default.
- W2032321569 cites W1972500026 @default.
- W2032321569 cites W1976219141 @default.
- W2032321569 cites W1977817124 @default.
- W2032321569 cites W1984507903 @default.
- W2032321569 cites W1985498851 @default.
- W2032321569 cites W1987198104 @default.
- W2032321569 cites W1989277130 @default.
- W2032321569 cites W1996311437 @default.
- W2032321569 cites W1998032181 @default.
- W2032321569 cites W2004536195 @default.
- W2032321569 cites W2006059185 @default.
- W2032321569 cites W2010415721 @default.
- W2032321569 cites W2011657572 @default.
- W2032321569 cites W2011817526 @default.
- W2032321569 cites W2018974184 @default.
- W2032321569 cites W2019443502 @default.
- W2032321569 cites W2022288325 @default.
- W2032321569 cites W2024768658 @default.
- W2032321569 cites W2034777022 @default.
- W2032321569 cites W2035142466 @default.
- W2032321569 cites W2040987676 @default.
- W2032321569 cites W2043079388 @default.
- W2032321569 cites W2043832602 @default.
- W2032321569 cites W2044627978 @default.
- W2032321569 cites W2047857041 @default.
- W2032321569 cites W2049054934 @default.
- W2032321569 cites W2049888915 @default.
- W2032321569 cites W2056880208 @default.
- W2032321569 cites W2058398958 @default.
- W2032321569 cites W2062523063 @default.
- W2032321569 cites W2062781235 @default.
- W2032321569 cites W2066070672 @default.
- W2032321569 cites W2066209708 @default.
- W2032321569 cites W2068082089 @default.
- W2032321569 cites W2068609215 @default.
- W2032321569 cites W2072860074 @default.
- W2032321569 cites W2074833985 @default.
- W2032321569 cites W2080543814 @default.
- W2032321569 cites W2082077073 @default.
- W2032321569 cites W2082137621 @default.
- W2032321569 cites W2082271081 @default.
- W2032321569 cites W2084799423 @default.
- W2032321569 cites W2085842761 @default.
- W2032321569 cites W2087848764 @default.
- W2032321569 cites W2092353110 @default.
- W2032321569 cites W2093131325 @default.
- W2032321569 cites W2093689511 @default.
- W2032321569 cites W2094326839 @default.
- W2032321569 cites W2095151749 @default.
- W2032321569 cites W2104979561 @default.
- W2032321569 cites W2106212803 @default.
- W2032321569 cites W2110514041 @default.
- W2032321569 cites W2112175087 @default.
- W2032321569 cites W2122896910 @default.
- W2032321569 cites W2124120422 @default.
- W2032321569 cites W2125938806 @default.
- W2032321569 cites W2129543544 @default.
- W2032321569 cites W2132652745 @default.
- W2032321569 cites W2133324295 @default.
- W2032321569 cites W2134369482 @default.
- W2032321569 cites W2134787735 @default.
- W2032321569 cites W2135387829 @default.
- W2032321569 cites W2137914523 @default.
- W2032321569 cites W2138233204 @default.
- W2032321569 cites W2138310386 @default.
- W2032321569 cites W2141533937 @default.
- W2032321569 cites W2145391370 @default.
- W2032321569 cites W2148923601 @default.
- W2032321569 cites W2152252699 @default.
- W2032321569 cites W2158286282 @default.
- W2032321569 cites W2160982712 @default.
- W2032321569 cites W2161919155 @default.
- W2032321569 cites W2172018104 @default.
- W2032321569 cites W2179417997 @default.
- W2032321569 cites W2314152567 @default.
- W2032321569 cites W2185387556 @default.
- W2032321569 doi "https://doi.org/10.2174/157340708786305952" @default.
- W2032321569 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2756717" @default.
- W2032321569 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/19809592" @default.
- W2032321569 hasPublicationYear "2008" @default.
- W2032321569 type Work @default.
- W2032321569 sameAs 2032321569 @default.