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- W2032321602 abstract "Background . Cutaneous malignant melanoma (CMM) is a heterogeneous disease, acknowledged for its lack of predictability regarding clinical evolution. In order to appreciate a patient’s individual prognosis, an attempt is made to find new tumor markers that parallel the disease progression. Objective . To identify if melanoma inhibitory activity (MIA) protein could represent a tool for selecting high risk early stages melanoma patients. Method . Between 2008 and 2013, 155 patients with CMM were treated in our clinic. 84 of them were classified into stages I and II, according to TNM 2009. MIA serum concentration was measured in all patients and 50 healthy donors. A cut-off value of 9.4 ng/ml was established using the ROC curve. Results . All patients were followed up by periodic investigations every 6 months. We have noticed that 66% of patients with MIA serum values at diagnosis greater than 9.4 ng/mL have relapsed, while only 5% of patients with MIA serum concentration below the estimated threshold, recurred during the follow-up period<mml:math xmlns:mml=http://www.w3.org/1998/Math/MathML id=M1><mml:mo stretchy=false>(</mml:mo><mml:mi>P</mml:mi><mml:mo>=</mml:mo><mml:mn>0.000</mml:mn><mml:mo stretchy=false>)</mml:mo></mml:math>. The death risk was 12 times higher in pathological MIA group of patients<mml:math xmlns:mml=http://www.w3.org/1998/Math/MathML id=M2><mml:mo stretchy=false>(</mml:mo><mml:mi>P</mml:mi><mml:mo>=</mml:mo><mml:mn>0.0001</mml:mn><mml:mo stretchy=false>)</mml:mo></mml:math>. Conclusions . Our data suggest that MIA is an independent prognostic factor for patients with localized CMM." @default.
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- W2032321602 date "2014-01-01" @default.
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- W2032321602 title "Prognostic Value of Melanoma Inhibitory Activity Protein in Localized Cutaneous Malignant Melanoma" @default.
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- W2032321602 doi "https://doi.org/10.1155/2014/843214" @default.
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