Matches in SemOpenAlex for { <https://semopenalex.org/work/W2032336700> ?p ?o ?g. }
- W2032336700 endingPage "229" @default.
- W2032336700 startingPage "221" @default.
- W2032336700 abstract "Bisphosphonates (BPs) are now the most widely used drugs for diseases associated with increased bone resorption, such as osteoporosis, and tumor bone diseases. A significant drawback of the BPs is their poor oral absorption that is enhanced by the presence of bile acid substituents in the bisphosphonate framework, with no toxic effects. A straightforward synthesis of bile acid-containing hydroxy-bisphosphonates and a full characterization of these pharmaceutically important molecules, including an evaluation of affinity and the mechanism of binding to hydroxyapatite, is presented. The biological activity of bile acid-containing bisphosphonate salts was determined using the neutral-red assay on the L929 cell line and primary cultures of osteoclasts. The bioactivity of the new compounds was found superior than bisphosphonates of established activity." @default.
- W2032336700 created "2016-06-24" @default.
- W2032336700 creator A5001011002 @default.
- W2032336700 creator A5011457550 @default.
- W2032336700 creator A5023691791 @default.
- W2032336700 creator A5046025884 @default.
- W2032336700 creator A5055307549 @default.
- W2032336700 creator A5062523604 @default.
- W2032336700 creator A5069946077 @default.
- W2032336700 creator A5090901849 @default.
- W2032336700 date "2012-06-01" @default.
- W2032336700 modified "2023-09-24" @default.
- W2032336700 title "Synthesis, characterization and biological activity of hydroxyl-bisphosphonic analogs of bile acids" @default.
- W2032336700 cites W1963693385 @default.
- W2032336700 cites W1965065271 @default.
- W2032336700 cites W1968089570 @default.
- W2032336700 cites W1970126262 @default.
- W2032336700 cites W1972828885 @default.
- W2032336700 cites W1988497176 @default.
- W2032336700 cites W1991178917 @default.
- W2032336700 cites W2000680050 @default.
- W2032336700 cites W2007697964 @default.
- W2032336700 cites W2013801985 @default.
- W2032336700 cites W2017267215 @default.
- W2032336700 cites W2021313546 @default.
- W2032336700 cites W2025672294 @default.
- W2032336700 cites W2027378713 @default.
- W2032336700 cites W2034240362 @default.
- W2032336700 cites W2034946707 @default.
- W2032336700 cites W2035127727 @default.
- W2032336700 cites W2035311100 @default.
- W2032336700 cites W2045747724 @default.
- W2032336700 cites W2055430833 @default.
- W2032336700 cites W2066342798 @default.
- W2032336700 cites W2070315057 @default.
- W2032336700 cites W2075939968 @default.
- W2032336700 cites W2083254426 @default.
- W2032336700 cites W2084865918 @default.
- W2032336700 cites W2086669135 @default.
- W2032336700 cites W2086876971 @default.
- W2032336700 cites W2089480064 @default.
- W2032336700 cites W2089530266 @default.
- W2032336700 cites W2094396792 @default.
- W2032336700 cites W2107740998 @default.
- W2032336700 cites W2122732781 @default.
- W2032336700 cites W2128778774 @default.
- W2032336700 cites W2134304734 @default.
- W2032336700 cites W2168222534 @default.
- W2032336700 cites W2338225958 @default.
- W2032336700 cites W2951069909 @default.
- W2032336700 cites W4230844528 @default.
- W2032336700 cites W4243745146 @default.
- W2032336700 doi "https://doi.org/10.1016/j.ejmech.2012.03.020" @default.
- W2032336700 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/22483634" @default.
- W2032336700 hasPublicationYear "2012" @default.
- W2032336700 type Work @default.
- W2032336700 sameAs 2032336700 @default.
- W2032336700 citedByCount "16" @default.
- W2032336700 countsByYear W20323367002013 @default.
- W2032336700 countsByYear W20323367002014 @default.
- W2032336700 countsByYear W20323367002015 @default.
- W2032336700 countsByYear W20323367002016 @default.
- W2032336700 countsByYear W20323367002017 @default.
- W2032336700 countsByYear W20323367002020 @default.
- W2032336700 countsByYear W20323367002021 @default.
- W2032336700 countsByYear W20323367002022 @default.
- W2032336700 crossrefType "journal-article" @default.
- W2032336700 hasAuthorship W2032336700A5001011002 @default.
- W2032336700 hasAuthorship W2032336700A5011457550 @default.
- W2032336700 hasAuthorship W2032336700A5023691791 @default.
- W2032336700 hasAuthorship W2032336700A5046025884 @default.
- W2032336700 hasAuthorship W2032336700A5055307549 @default.
- W2032336700 hasAuthorship W2032336700A5062523604 @default.
- W2032336700 hasAuthorship W2032336700A5069946077 @default.
- W2032336700 hasAuthorship W2032336700A5090901849 @default.
- W2032336700 hasConcept C116073593 @default.
- W2032336700 hasConcept C126322002 @default.
- W2032336700 hasConcept C185592680 @default.
- W2032336700 hasConcept C202751555 @default.
- W2032336700 hasConcept C2776541429 @default.
- W2032336700 hasConcept C2777251235 @default.
- W2032336700 hasConcept C2779399885 @default.
- W2032336700 hasConcept C2908539429 @default.
- W2032336700 hasConcept C55493867 @default.
- W2032336700 hasConcept C673006 @default.
- W2032336700 hasConcept C71924100 @default.
- W2032336700 hasConceptScore W2032336700C116073593 @default.
- W2032336700 hasConceptScore W2032336700C126322002 @default.
- W2032336700 hasConceptScore W2032336700C185592680 @default.
- W2032336700 hasConceptScore W2032336700C202751555 @default.
- W2032336700 hasConceptScore W2032336700C2776541429 @default.
- W2032336700 hasConceptScore W2032336700C2777251235 @default.
- W2032336700 hasConceptScore W2032336700C2779399885 @default.
- W2032336700 hasConceptScore W2032336700C2908539429 @default.
- W2032336700 hasConceptScore W2032336700C55493867 @default.
- W2032336700 hasConceptScore W2032336700C673006 @default.
- W2032336700 hasConceptScore W2032336700C71924100 @default.
- W2032336700 hasLocation W20323367001 @default.