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• W2032344343 abstract "Objective . To develop and test a risk-scoring model for the prediction of endometrial cancer among symptomatic postmenopausal women at risk of intrauterine malignancy. Methods . We prospectively studied 624 postmenopausal women with vaginal bleeding and endometrial thickness > 4 mm undergoing diagnostic hysteroscopy. Patient characteristics and endometrial assessment of women with or without endometrial cancer were compared. Then, a risk-scoring model, including the best predictors of endometrial cancer, was tested. Univariate, multivariate, and ROC curve analysis were performed. Finally, a split-sampling internal validation was also performed. Results . The best predictors of endometrial cancer were recurrent vaginal bleeding (odds ratio<mml:math xmlns:mml=http://www.w3.org/1998/Math/MathML id=M1><mml:mo stretchy=false>(</mml:mo><mml:mtext>OR</mml:mtext><mml:mo stretchy=false>)</mml:mo><mml:mo>=</mml:mo><mml:mn>2.96</mml:mn></mml:math>), the presence of hypertension<mml:math xmlns:mml=http://www.w3.org/1998/Math/MathML id=M2><mml:mo stretchy=false>(</mml:mo><mml:mtext>OR</mml:mtext><mml:mo>=</mml:mo><mml:mn>2.01</mml:mn><mml:mo stretchy=false>)</mml:mo></mml:math>endometrial thickness > 8 mm<mml:math xmlns:mml=http://www.w3.org/1998/Math/MathML id=M3><mml:mo stretchy=false>(</mml:mo><mml:mtext>OR</mml:mtext><mml:mo>=</mml:mo><mml:mn>1.31</mml:mn><mml:mo stretchy=false>)</mml:mo></mml:math>, and age > 65 years<mml:math xmlns:mml=http://www.w3.org/1998/Math/MathML id=M4><mml:mo stretchy=false>(</mml:mo><mml:mtext>OR</mml:mtext><mml:mo>=</mml:mo><mml:mn>1.11</mml:mn><mml:mo stretchy=false>)</mml:mo></mml:math>. These variables were used to create a risk-scoring model (RHEA risk-model) for the prediction of intrauterine malignancy, with an area under the curve of 0.878 (95% CI 0.842 to 0.908;<mml:math xmlns:mml=http://www.w3.org/1998/Math/MathML id=M5><mml:mi>P</mml:mi><mml:mo><</mml:mo><mml:mn>0.0001</mml:mn></mml:math>). At the best cut-off value (score ≥ 4), sensitivity and specificity were 87.5% and 80.1%, respectively. Conclusion . Among symptomatic postmenopausal women with endometrial thickness > 4 mm, a risk-scoring model including patient characteristics and endometrial thickness showed a moderate diagnostic accuracy in discriminating women with or without endometrial cancer. Based on this model, a decision algorithm was developed for the management of such a population." @default.
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• W2032344343 date "2014-01-01" @default.
• W2032344343 modified "2023-10-12" @default.
• W2032344343 title "A Risk-Scoring Model for the Prediction of Endometrial Cancer among Symptomatic Postmenopausal Women with Endometrial Thickness > 4 mm" @default.
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• W2032344343 doi "https://doi.org/10.1155/2014/130569" @default.
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