FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2032355755> ?p ?o ?g. }

• W2032355755 abstract "Abstract Background Glutaminase predominates in periportal hepatocytes and it has been proposed that it determines the glutamine-derived nitrogen flow through the urea cycle. Glutamine-derived urea production should, thus, be considerably faster in periportal hepatocytes. This postulate, based on indirect observations, has not yet been unequivocally demonstrated, making a direct investigation of ureogenesis from glutamine highly desirable. Methods Zonation of glutamine metabolism was investigated in the bivascularly perfused rat liver with [U- 14 C]glutamine infusion (0.6 mM) into the portal vein (antegrade perfusion) or into the hepatic vein (retrograde perfusion). Results Ammonia infusion into the hepatic artery in retrograde and antegrade perfusion allowed to promote glutamine metabolism in the periportal region and in the whole liver parenchyma, respectively. The results revealed that the space-normalized glutamine uptake, indicated by 14 CO 2 production, gluconeogenesis, lactate production and the associated oxygen uptake, predominates in the periportal region. Periportal predominance was especially pronounced for gluconeogenesis. Ureogenesis, however, tended to be uniformly distributed over the whole liver parenchyma at low ammonia concentrations (up to 1.0 mM); periportal predominance was found only at ammonia concentrations above 1 mM. The proportions between the carbon and nitrogen fluxes in periportal cells are not the same along the liver acinus. Conclusions In conclusion, the results of the present work indicate that the glutaminase activity in periportal hepatocytes is not the rate-controlling step of the glutamine-derived nitrogen flow through the urea cycle. The findings corroborate recent work indicating that ureogenesis is also an important ammonia-detoxifying mechanism in cells situated downstream to the periportal region." @default.
• W2032355755 created "2016-06-24" @default.
• W2032355755 creator A5002976518 @default.
• W2032355755 creator A5020164379 @default.
• W2032355755 creator A5041298191 @default.
• W2032355755 creator A5061607550 @default.
• W2032355755 date "2010-01-07" @default.
• W2032355755 modified "2023-10-15" @default.
• W2032355755 title "Hepatic zonation of carbon and nitrogen fluxes derived from glutamine and ammonia transformations" @default.
• W2032355755 cites W107868517 @default.
• W2032355755 cites W1494422363 @default.
• W2032355755 cites W1566104504 @default.
• W2032355755 cites W1929778487 @default.
• W2032355755 cites W1964283284 @default.
• W2032355755 cites W1981595029 @default.
• W2032355755 cites W1983581077 @default.
• W2032355755 cites W1983979503 @default.
• W2032355755 cites W2001972155 @default.
• W2032355755 cites W2007473072 @default.
• W2032355755 cites W2014829648 @default.
• W2032355755 cites W2019892851 @default.
• W2032355755 cites W2031402631 @default.
• W2032355755 cites W2034248880 @default.
• W2032355755 cites W2052702347 @default.
• W2032355755 cites W2060967631 @default.
• W2032355755 cites W2061538287 @default.
• W2032355755 cites W2091257592 @default.
• W2032355755 cites W2091822932 @default.
• W2032355755 cites W2096471914 @default.
• W2032355755 cites W2145130695 @default.
• W2032355755 cites W2168498504 @default.
• W2032355755 cites W2205407710 @default.
• W2032355755 cites W2281343124 @default.
• W2032355755 cites W2395393154 @default.
• W2032355755 cites W2399963799 @default.
• W2032355755 cites W2992133041 @default.
• W2032355755 doi "https://doi.org/10.1186/1423-0127-17-1" @default.
• W2032355755 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2843605" @default.
• W2032355755 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/20055990" @default.
• W2032355755 hasPublicationYear "2010" @default.
• W2032355755 type Work @default.
• W2032355755 sameAs 2032355755 @default.
• W2032355755 citedByCount "37" @default.
• W2032355755 countsByYear W20323557552012 @default.
• W2032355755 countsByYear W20323557552013 @default.
• W2032355755 countsByYear W20323557552014 @default.
• W2032355755 countsByYear W20323557552015 @default.
• W2032355755 countsByYear W20323557552016 @default.
• W2032355755 countsByYear W20323557552017 @default.
• W2032355755 countsByYear W20323557552019 @default.
• W2032355755 countsByYear W20323557552020 @default.
• W2032355755 countsByYear W20323557552021 @default.
• W2032355755 countsByYear W20323557552022 @default.
• W2032355755 countsByYear W20323557552023 @default.
• W2032355755 crossrefType "journal-article" @default.
• W2032355755 hasAuthorship W2032355755A5002976518 @default.
• W2032355755 hasAuthorship W2032355755A5020164379 @default.
• W2032355755 hasAuthorship W2032355755A5041298191 @default.
• W2032355755 hasAuthorship W2032355755A5061607550 @default.
• W2032355755 hasBestOaLocation W20323557551 @default.
• W2032355755 hasConcept C109549099 @default.
• W2032355755 hasConcept C126322002 @default.
• W2032355755 hasConcept C134018914 @default.
• W2032355755 hasConcept C146957229 @default.
• W2032355755 hasConcept C170493617 @default.
• W2032355755 hasConcept C178790620 @default.
• W2032355755 hasConcept C185592680 @default.
• W2032355755 hasConcept C196822366 @default.
• W2032355755 hasConcept C2776382133 @default.
• W2032355755 hasConcept C2777202666 @default.
• W2032355755 hasConcept C2777468819 @default.
• W2032355755 hasConcept C2779289688 @default.
• W2032355755 hasConcept C2779349466 @default.
• W2032355755 hasConcept C2779389133 @default.
• W2032355755 hasConcept C2780365088 @default.
• W2032355755 hasConcept C515207424 @default.
• W2032355755 hasConcept C537208039 @default.
• W2032355755 hasConcept C55493867 @default.
• W2032355755 hasConcept C59822182 @default.
• W2032355755 hasConcept C61174792 @default.
• W2032355755 hasConcept C62231903 @default.
• W2032355755 hasConcept C71924100 @default.
• W2032355755 hasConcept C77061444 @default.
• W2032355755 hasConcept C86803240 @default.
• W2032355755 hasConceptScore W2032355755C109549099 @default.
• W2032355755 hasConceptScore W2032355755C126322002 @default.
• W2032355755 hasConceptScore W2032355755C134018914 @default.
• W2032355755 hasConceptScore W2032355755C146957229 @default.
• W2032355755 hasConceptScore W2032355755C170493617 @default.
• W2032355755 hasConceptScore W2032355755C178790620 @default.
• W2032355755 hasConceptScore W2032355755C185592680 @default.
• W2032355755 hasConceptScore W2032355755C196822366 @default.
• W2032355755 hasConceptScore W2032355755C2776382133 @default.
• W2032355755 hasConceptScore W2032355755C2777202666 @default.
• W2032355755 hasConceptScore W2032355755C2777468819 @default.
• W2032355755 hasConceptScore W2032355755C2779289688 @default.
• W2032355755 hasConceptScore W2032355755C2779349466 @default.
• W2032355755 hasConceptScore W2032355755C2779389133 @default.
• W2032355755 hasConceptScore W2032355755C2780365088 @default.
• W2032355755 hasConceptScore W2032355755C515207424 @default.

• next