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- W2032363524 abstract "We cloned by phenotypic complementation a novel Saccharomyces cerevlslae's multicopy suppressor of the Schizosaccharomyces pombe cddO-129 mutant which we call HAC1, an acronym of 'homologous to ATF/CREB 1'. It encodes a bZIP (basic-leucine zipper) protein of 230 amlno acids with close homology to the mammalian ATF/CREB transcription factor and gel-retardation assays showed that it binds specifically to the CRE motif. HAC1 is not essential for viability. However, the had disruptant becomes caffeine sensitive, which is suppressed by multicopy expression of the yeast PDE2 (Phosphodlesterase 2) gene. Although the mRNA level of HAC1 is almost constitutive throughout the cell cycle, It fluctuates during meiosis. The upstream region of the HAC1 gene contains a T4C site, a URS (upstream repression sequence) and a TR (T-rlch) box-like sequence, which reside upstream of many meiotic genes. These results suggest that HAC1 may also be one of the meiotic genes." @default.
- W2032363524 created "2016-06-24" @default.
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- W2032363524 date "1994-01-01" @default.
- W2032363524 modified "2023-09-23" @default.
- W2032363524 title "Hac1: A novel yeast bZIP protein binding to the CRE motif is a multicopy suppressor for cdcW mutant of Schizosaccharomyces pombe" @default.
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- W2032363524 doi "https://doi.org/10.1093/nar/22.24.5279" @default.
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