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- W2032374665 endingPage "14" @default.
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- W2032374665 abstract "Ocular gene therapy is rapidly becoming a reality. By November 2012, approximately 28 clinical trials were approved to assess novel gene therapy agents. Viral infections such as herpetic keratitis caused by herpes simplex virus 1 (HSV-1) can cause serious complications that may lead to blindness. Recurrence of the disease is likely and cornea transplantation, therefore, might not be the ideal therapeutic solution. This paper will focus on the current situation of ocular gene therapy research against herpetic keratitis, including the use of viral and nonviral vectors, routes of delivery of therapeutic genes, new techniques, and key research strategies. Whereas the correction of inherited diseases was the initial goal of the field of gene therapy, here we discuss transgene expression, gene replacement, silencing, or clipping. Gene therapy of herpetic keratitis previously reported in the literature is screened emphasizing candidate gene therapy targets. Commonly adopted strategies are discussed to assess the relative advantages of the protective therapy using antiviral drugs and the common gene therapy against long-term HSV-1 ocular infections signs, inflammation and neovascularization. Successful gene therapy can provide innovative physiological and pharmaceutical solutions against herpetic keratitis." @default.
- W2032374665 created "2016-06-24" @default.
- W2032374665 creator A5006643879 @default.
- W2032374665 creator A5050932223 @default.
- W2032374665 creator A5073374573 @default.
- W2032374665 creator A5080148401 @default.
- W2032374665 creator A5084716547 @default.
- W2032374665 date "2012-01-01" @default.
- W2032374665 modified "2023-09-27" @default.
- W2032374665 title "Targeting Herpetic Keratitis by Gene Therapy" @default.
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