FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2032383669> ?p ?o ?g. }

• W2032383669 endingPage "718" @default.
• W2032383669 startingPage "707" @default.
• W2032383669 abstract "Efforts to develop immune-based therapies for HIV infection have been impeded by incomplete definition of the immunological correlates of protection. Despite many precedents demonstrating that CD8(+) cytotoxic T lymphocytes are key mediators of protective anti-viral immunity in non-human animal models, direct evidence that these effector cells control viral replication in HIV-1 infection has remained elusive. The first part of this paper describes a detailed immunological and genetic study founded on evolutionary considerations. Following infection with HIV-1, virus variants which escaped recognition by autologous cytotoxic T lymphocytes were shown to possess a selection advantage within the host environment. Cytotoxic T lymphocytes therefore exert anti-viral pressure in vivo. This observation provides compelling evidence that cytotoxic T lymphocytes comprise a significant element of anti-retroviral immunity. Subsequently, the quantification of peripheral cytotoxic T lymphocyte frequencies utilizing peptide-(human leucocyte antigen class I) tetrameric complexes is described. Five patients with qualitatively similar immunodominant cytotoxic T lymphocyte responses during symptomatic primary HIV-1 infection were studied longitudinally. Expansions of virus-specific CD8(+) lymphocytes comprising up to 2% of the total CD8(+) T cell population were observed in the acute phase of infection. Antigenic load was identified as an important determinant of circulating HIV-1-specific CD8(+) lymphocyte levels; however, significant numbers of such cells were also found to persist following prolonged therapeutic suppression of plasma viraemia. In addition, an analysis of antigenic sequence variation with time in this case series suggests that the early administration of combination anti-retroviral therapy may limit HIV-1 mutational escape from host cytolytic specificities. The implications of these preliminary data are discussed. The data presented suggest that vaccination protocols should aim to elicit vigorous cytotoxic T lymphocyte responses to HIV-1. Attempts to stimulate polyvalent responses to mutationally intolerant epitopes are likely to be most effective. Optimal management of HIV-1 infection requires an understanding of dynamic host-virus interactions, and may involve strategies designed to enhance cytotoxic T lymphocyte activity following periods of anti-retroviral drug therapy." @default.
• W2032383669 created "2016-06-24" @default.
• W2032383669 creator A5001255253 @default.
• W2032383669 creator A5006556270 @default.
• W2032383669 creator A5023823568 @default.
• W2032383669 creator A5046316209 @default.
• W2032383669 creator A5058664398 @default.
• W2032383669 date "1999-11-15" @default.
• W2032383669 modified "2023-09-26" @default.
• W2032383669 title "Cytotoxic T lymphocytes and viral evolution in primary HIV-1 infection" @default.
• W2032383669 cites W1481708591 @default.
• W2032383669 cites W1565817207 @default.
• W2032383669 cites W1603523611 @default.
• W2032383669 cites W1655510925 @default.
• W2032383669 cites W1907806866 @default.
• W2032383669 cites W1969899610 @default.
• W2032383669 cites W1973398091 @default.
• W2032383669 cites W1974807329 @default.
• W2032383669 cites W1974839791 @default.
• W2032383669 cites W1977506425 @default.
• W2032383669 cites W1979773132 @default.
• W2032383669 cites W1980587508 @default.
• W2032383669 cites W1986152436 @default.
• W2032383669 cites W1986810912 @default.
• W2032383669 cites W1995380235 @default.
• W2032383669 cites W1996210947 @default.
• W2032383669 cites W1996464851 @default.
• W2032383669 cites W2002062046 @default.
• W2032383669 cites W2006597943 @default.
• W2032383669 cites W2009241821 @default.
• W2032383669 cites W2011630381 @default.
• W2032383669 cites W2012139740 @default.
• W2032383669 cites W2019231040 @default.
• W2032383669 cites W2020096299 @default.
• W2032383669 cites W2022291864 @default.
• W2032383669 cites W2022762562 @default.
• W2032383669 cites W2026668380 @default.
• W2032383669 cites W2027051533 @default.
• W2032383669 cites W2030844138 @default.
• W2032383669 cites W2037343680 @default.
• W2032383669 cites W2037793240 @default.
• W2032383669 cites W2038530210 @default.
• W2032383669 cites W2044587042 @default.
• W2032383669 cites W2047269867 @default.
• W2032383669 cites W2065740427 @default.
• W2032383669 cites W2067069532 @default.
• W2032383669 cites W2067758651 @default.
• W2032383669 cites W2070837106 @default.
• W2032383669 cites W2071459721 @default.
• W2032383669 cites W2075135942 @default.
• W2032383669 cites W2079230020 @default.
• W2032383669 cites W2079504777 @default.
• W2032383669 cites W2079542677 @default.
• W2032383669 cites W2081550246 @default.
• W2032383669 cites W2082814103 @default.
• W2032383669 cites W2085919513 @default.
• W2032383669 cites W2090646713 @default.
• W2032383669 cites W2094583956 @default.
• W2032383669 cites W2095922293 @default.
• W2032383669 cites W2096644099 @default.
• W2032383669 cites W2103182811 @default.
• W2032383669 cites W2106628454 @default.
• W2032383669 cites W2126302947 @default.
• W2032383669 cites W2127552260 @default.
• W2032383669 cites W2129114331 @default.
• W2032383669 cites W2130612676 @default.
• W2032383669 cites W2131609927 @default.
• W2032383669 cites W2137426528 @default.
• W2032383669 cites W2139250164 @default.
• W2032383669 cites W2144882745 @default.
• W2032383669 cites W2145517219 @default.
• W2032383669 cites W2150492554 @default.
• W2032383669 cites W2152416144 @default.
• W2032383669 cites W2156110652 @default.
• W2032383669 cites W2163345314 @default.
• W2032383669 cites W2163386497 @default.
• W2032383669 cites W2166883229 @default.
• W2032383669 cites W2168932061 @default.
• W2032383669 cites W2170219825 @default.
• W2032383669 cites W2320150009 @default.
• W2032383669 cites W2336115893 @default.
• W2032383669 cites W2339173512 @default.
• W2032383669 cites W2411895135 @default.
• W2032383669 doi "https://doi.org/10.1042/cs0970707" @default.
• W2032383669 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/10585898" @default.
• W2032383669 hasPublicationYear "1999" @default.
• W2032383669 type Work @default.
• W2032383669 sameAs 2032383669 @default.
• W2032383669 citedByCount "13" @default.
• W2032383669 countsByYear W20323836692012 @default.
• W2032383669 countsByYear W20323836692016 @default.
• W2032383669 countsByYear W20323836692020 @default.
• W2032383669 crossrefType "journal-article" @default.
• W2032383669 hasAuthorship W2032383669A5001255253 @default.
• W2032383669 hasAuthorship W2032383669A5006556270 @default.
• W2032383669 hasAuthorship W2032383669A5023823568 @default.
• W2032383669 hasAuthorship W2032383669A5046316209 @default.
• W2032383669 hasAuthorship W2032383669A5058664398 @default.

• next