FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2032383741> ?p ?o ?g. }

• W2032383741 abstract "The purified cytosolic 3 alpha-hydroxysteroid oxidoreductase (3 alpha-HSOR) from female rat pituitary which catalyzes the reversible conversion of 5 alpha-dihydroprogesterone (5 alpha-DHP) to 3 alpha, 5 alpha-tetrahydroprogesterone (3 alpha, 5 alpha-THP) has been characterized in terms of its steroid substrate specificity, dihydrodiol dehydrogenase activity and inhibition by drugs such as medroxyprogesterone and indomethacin. The purified enzyme has a strong preference for the C21 progestin steroid substrates, 5 alpha-DHP and 3 alpha, 5 alpha-THP, over the corresponding C19 androgenic steroid substrates, 5 alpha-dihydrotesterone (5 alpha-DHT) and 3 alpha, 5 alpha-tetrahydrotestosterone (3 alpha, 5 alpha-THT). The apparent Km for 5 alpha-DHP (80 nM) is about 250 times lower than the Km for the androgenic steroid, 5 alpha-DHT (21 microM). In the oxidative direction, the apparent Km for 3 alpha, 5 alpha-TP (1.4 microM) is about 3-fold lower than the Km for the androgenic steroid, 3 alpha, 5 alpha-THT (4.2 microM). A number of other naturally occurring 3-keto- and 3 alpha(beta)-hydroxy-steroids were assessed for their ability to act as inhibitors (alternate substrates) of the 3 alpha-reduction of 5 alpha-DHP catalyzed by the purified 3 alpha-HSOR. None of the 3 beta- or 5 beta-isomers had any effect. Of the other 3-keto and 3 alpha- steroids tested, only deoxycorticosterone and the ovarian progestins showed any significant inhibition. These may be acting as inhibitors since there was little, if any, direct 3 alpha-reduction of progesterone to 3 alpha-hydroxy-4-pregnen-20-one. Unlike the liver cytosolic 3 alpha-HSOR, the pituitary enzyme has no associated dihydrodiol (quinone) dehydrogenase activity. This enzyme is similar to other cytosolic 3 alpha-HSORs from liver and brain in that it is potentially inhibited by indomethacin and by medroxyprogesterone." @default.
• W2032383741 created "2016-06-24" @default.
• W2032383741 creator A5067874853 @default.
• W2032383741 creator A5087187593 @default.
• W2032383741 date "1990-11-01" @default.
• W2032383741 modified "2023-10-17" @default.
• W2032383741 title "Characterization of the purified pituitary cytosolic NADPH: 5α-dihydroprogesterone 3α-hydroxysteroid oxidoreductase" @default.
• W2032383741 cites W137003654 @default.
• W2032383741 cites W1512158712 @default.
• W2032383741 cites W1561395636 @default.
• W2032383741 cites W1588920488 @default.
• W2032383741 cites W1620990221 @default.
• W2032383741 cites W1964906892 @default.
• W2032383741 cites W1966151647 @default.
• W2032383741 cites W1974533886 @default.
• W2032383741 cites W1974962364 @default.
• W2032383741 cites W1982627216 @default.
• W2032383741 cites W1990042399 @default.
• W2032383741 cites W2005825980 @default.
• W2032383741 cites W2027490693 @default.
• W2032383741 cites W2033385789 @default.
• W2032383741 cites W2058869559 @default.
• W2032383741 cites W2063439191 @default.
• W2032383741 cites W2063845813 @default.
• W2032383741 cites W2068909130 @default.
• W2032383741 cites W2070403289 @default.
• W2032383741 cites W2083447043 @default.
• W2032383741 cites W2092060036 @default.
• W2032383741 cites W2092081763 @default.
• W2032383741 cites W2115537559 @default.
• W2032383741 cites W2121709251 @default.
• W2032383741 cites W43526258 @default.
• W2032383741 doi "https://doi.org/10.1016/0960-0760(90)90398-5" @default.
• W2032383741 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/2278837" @default.
• W2032383741 hasPublicationYear "1990" @default.
• W2032383741 type Work @default.
• W2032383741 sameAs 2032383741 @default.
• W2032383741 citedByCount "21" @default.
• W2032383741 crossrefType "journal-article" @default.
• W2032383741 hasAuthorship W2032383741A5067874853 @default.
• W2032383741 hasAuthorship W2032383741A5087187593 @default.
• W2032383741 hasConcept C121608353 @default.
• W2032383741 hasConcept C126322002 @default.
• W2032383741 hasConcept C134018914 @default.
• W2032383741 hasConcept C159110408 @default.
• W2032383741 hasConcept C181199279 @default.
• W2032383741 hasConcept C185592680 @default.
• W2032383741 hasConcept C2775874879 @default.
• W2032383741 hasConcept C2775944032 @default.
• W2032383741 hasConcept C2776235491 @default.
• W2032383741 hasConcept C2776317432 @default.
• W2032383741 hasConcept C2776888042 @default.
• W2032383741 hasConcept C2778683662 @default.
• W2032383741 hasConcept C2779268744 @default.
• W2032383741 hasConcept C2780902042 @default.
• W2032383741 hasConcept C2910366748 @default.
• W2032383741 hasConcept C49453240 @default.
• W2032383741 hasConcept C55493867 @default.
• W2032383741 hasConcept C64943373 @default.
• W2032383741 hasConcept C71240020 @default.
• W2032383741 hasConcept C71315377 @default.
• W2032383741 hasConcept C71924100 @default.
• W2032383741 hasConcept C86803240 @default.
• W2032383741 hasConcept C98539663 @default.
• W2032383741 hasConceptScore W2032383741C121608353 @default.
• W2032383741 hasConceptScore W2032383741C126322002 @default.
• W2032383741 hasConceptScore W2032383741C134018914 @default.
• W2032383741 hasConceptScore W2032383741C159110408 @default.
• W2032383741 hasConceptScore W2032383741C181199279 @default.
• W2032383741 hasConceptScore W2032383741C185592680 @default.
• W2032383741 hasConceptScore W2032383741C2775874879 @default.
• W2032383741 hasConceptScore W2032383741C2775944032 @default.
• W2032383741 hasConceptScore W2032383741C2776235491 @default.
• W2032383741 hasConceptScore W2032383741C2776317432 @default.
• W2032383741 hasConceptScore W2032383741C2776888042 @default.
• W2032383741 hasConceptScore W2032383741C2778683662 @default.
• W2032383741 hasConceptScore W2032383741C2779268744 @default.
• W2032383741 hasConceptScore W2032383741C2780902042 @default.
• W2032383741 hasConceptScore W2032383741C2910366748 @default.
• W2032383741 hasConceptScore W2032383741C49453240 @default.
• W2032383741 hasConceptScore W2032383741C55493867 @default.
• W2032383741 hasConceptScore W2032383741C64943373 @default.
• W2032383741 hasConceptScore W2032383741C71240020 @default.
• W2032383741 hasConceptScore W2032383741C71315377 @default.
• W2032383741 hasConceptScore W2032383741C71924100 @default.
• W2032383741 hasConceptScore W2032383741C86803240 @default.
• W2032383741 hasConceptScore W2032383741C98539663 @default.
• W2032383741 hasLocation W20323837411 @default.
• W2032383741 hasLocation W20323837412 @default.
• W2032383741 hasOpenAccess W2032383741 @default.
• W2032383741 hasPrimaryLocation W20323837411 @default.
• W2032383741 hasRelatedWork W1992849382 @default.
• W2032383741 hasRelatedWork W2016509526 @default.
• W2032383741 hasRelatedWork W2024901198 @default.
• W2032383741 hasRelatedWork W2029501666 @default.
• W2032383741 hasRelatedWork W2032383741 @default.
• W2032383741 hasRelatedWork W2042981731 @default.
• W2032383741 hasRelatedWork W2063845813 @default.
• W2032383741 hasRelatedWork W2082130579 @default.
• W2032383741 hasRelatedWork W2111039542 @default.

• next