FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2032388082> ?p ?o ?g. }

• W2032388082 endingPage "1187" @default.
• W2032388082 startingPage "1182" @default.
• W2032388082 abstract "The development of gastric mucosa-associated lymphoid tissue (MALT) lymphoma is a multistep process and can be clinico-pathologically divided into Helicobacter pylori-associated gastritis, low-grade tumors, and high-grade tumors. The molecular events underlying this progression are largely unknown. However, identification of the genes involved in MALT lymphoma-specific t(11;18)(q21;q21) and t(1;14)(p22;q32) has provided fresh insights into the pathogenesis of this disease. T(11;18)(q21;q21) results in a chimeric transcript between the API2 and theMALT1 genes, whereas t(1;14) (p22;q32) causes aberrant nuclear BCL10 expression. Significantly, nuclear BCL10 expression also occurs frequently in MALT lymphomas without t(1;14)(p22;q32), suggesting an important role for BCL10 in lymphoma development. Thirty-three cases of H pylori gastritis, 72 MALT lymphomas, and 11 mucosal diffuse large B-cell lymphomas (DLBCL) were screened for t(11;18)(q21;q21) by reverse transcription–polymerase chain reaction followed by sequencing. BCL10 expression in lymphoma cases was examined by immunohistochemistry. The API2–MALT1 fusion transcript was not detected in H pylorigastritis and mucosal DLBCL but was found in 25 of 72 (35%) MALT lymphomas of various sites. Nuclear BCL10 expression was seen in 28 of 53 (53%) of MALT lymphomas. Of the gastric cases, the largest group studied, the frequency of both t(11;18)(q21;q21) and nuclear BCL10 expression was significantly higher in tumors that showed dissemination to local lymph nodes or distal sites (14 of 18 = 78% and 14 of 15 = 93%, respectively) than those confined to the stomach (3 of 29 = 10% and 10 of 26 = 38%). Furthermore, t(11;18)(q21;q21) closely correlated with BCL10 nuclear expression. These results indicate that both t(11;18)(q21;q21) and BCL10 nuclear expression are associated with advanced MALT lymphoma and that their oncogenic activities may be related to each other." @default.
• W2032388082 created "2016-06-24" @default.
• W2032388082 creator A5004200273 @default.
• W2032388082 creator A5015948461 @default.
• W2032388082 creator A5020421276 @default.
• W2032388082 creator A5024505450 @default.
• W2032388082 creator A5031600864 @default.
• W2032388082 creator A5046629044 @default.
• W2032388082 creator A5084576706 @default.
• W2032388082 creator A5086745354 @default.
• W2032388082 date "2001-08-15" @default.
• W2032388082 modified "2023-10-18" @default.
• W2032388082 title "T(11;18)(q21;q21) is associated with advanced mucosa-associated lymphoid tissue lymphoma that expresses nuclear BCL10" @default.
• W2032388082 cites W1520695706 @default.
• W2032388082 cites W1538281804 @default.
• W2032388082 cites W1563487810 @default.
• W2032388082 cites W1607483353 @default.
• W2032388082 cites W1831727331 @default.
• W2032388082 cites W1973519806 @default.
• W2032388082 cites W1987172924 @default.
• W2032388082 cites W1989287278 @default.
• W2032388082 cites W1996785805 @default.
• W2032388082 cites W1997640923 @default.
• W2032388082 cites W1999890924 @default.
• W2032388082 cites W2000594485 @default.
• W2032388082 cites W2003192378 @default.
• W2032388082 cites W2006338784 @default.
• W2032388082 cites W2010459522 @default.
• W2032388082 cites W2019137217 @default.
• W2032388082 cites W2021569848 @default.
• W2032388082 cites W2025635508 @default.
• W2032388082 cites W2030262603 @default.
• W2032388082 cites W2038426029 @default.
• W2032388082 cites W2040470196 @default.
• W2032388082 cites W2041170768 @default.
• W2032388082 cites W2042919664 @default.
• W2032388082 cites W2043102057 @default.
• W2032388082 cites W2043141000 @default.
• W2032388082 cites W2045205786 @default.
• W2032388082 cites W2047053776 @default.
• W2032388082 cites W2060076676 @default.
• W2032388082 cites W2072692243 @default.
• W2032388082 cites W2095340633 @default.
• W2032388082 cites W2097639928 @default.
• W2032388082 cites W2114290685 @default.
• W2032388082 cites W2114379972 @default.
• W2032388082 cites W2120492514 @default.
• W2032388082 cites W2124820921 @default.
• W2032388082 cites W2133308247 @default.
• W2032388082 cites W2141260928 @default.
• W2032388082 cites W2142693274 @default.
• W2032388082 cites W2158874809 @default.
• W2032388082 cites W2167490100 @default.
• W2032388082 cites W2259826284 @default.
• W2032388082 cites W2326124472 @default.
• W2032388082 cites W4248493569 @default.
• W2032388082 cites W4366064382 @default.
• W2032388082 cites W82942945 @default.
• W2032388082 doi "https://doi.org/10.1182/blood.v98.4.1182" @default.
• W2032388082 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/11493468" @default.
• W2032388082 hasPublicationYear "2001" @default.
• W2032388082 type Work @default.
• W2032388082 sameAs 2032388082 @default.
• W2032388082 citedByCount "229" @default.
• W2032388082 countsByYear W20323880822012 @default.
• W2032388082 countsByYear W20323880822013 @default.
• W2032388082 countsByYear W20323880822014 @default.
• W2032388082 countsByYear W20323880822015 @default.
• W2032388082 countsByYear W20323880822016 @default.
• W2032388082 countsByYear W20323880822017 @default.
• W2032388082 countsByYear W20323880822018 @default.
• W2032388082 countsByYear W20323880822019 @default.
• W2032388082 countsByYear W20323880822020 @default.
• W2032388082 countsByYear W20323880822021 @default.
• W2032388082 countsByYear W20323880822022 @default.
• W2032388082 countsByYear W20323880822023 @default.
• W2032388082 crossrefType "journal-article" @default.
• W2032388082 hasAuthorship W2032388082A5004200273 @default.
• W2032388082 hasAuthorship W2032388082A5015948461 @default.
• W2032388082 hasAuthorship W2032388082A5020421276 @default.
• W2032388082 hasAuthorship W2032388082A5024505450 @default.
• W2032388082 hasAuthorship W2032388082A5031600864 @default.
• W2032388082 hasAuthorship W2032388082A5046629044 @default.
• W2032388082 hasAuthorship W2032388082A5084576706 @default.
• W2032388082 hasAuthorship W2032388082A5086745354 @default.
• W2032388082 hasBestOaLocation W20323880821 @default.
• W2032388082 hasConcept C107006841 @default.
• W2032388082 hasConcept C142724271 @default.
• W2032388082 hasConcept C159654299 @default.
• W2032388082 hasConcept C181152851 @default.
• W2032388082 hasConcept C203014093 @default.
• W2032388082 hasConcept C2776409635 @default.
• W2032388082 hasConcept C2778453870 @default.
• W2032388082 hasConcept C2779338263 @default.
• W2032388082 hasConcept C2779526237 @default.
• W2032388082 hasConcept C2779851268 @default.
• W2032388082 hasConcept C502942594 @default.
• W2032388082 hasConcept C54355233 @default.

• next