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- W2032390903 abstract "The effect of mexiletine administration on steady-state plasma theophylline concentrations was studied in eight normal healthy men in a prospective open label nonrandomized two-way crossover trial. Repeated doses of 300 mg of sustained-release theophylline were given every 12 hours for 9 days. Mexiletine hydrochloride, 200 mg every 8 hours, was given for five consecutive doses starting on the morning of day 6. Mexiletine increased theophylline levels in all subjects. Mean predose (trough) levels rose from 8.1 ± 0.1 µg · ml−1 to 13.4 ± 0.6 µg · ml−1and AUC(0–12) from 96.8 ± 9.1 to 160.2 ± 3.7 µg · ml−1 · hr. Plasma clearance was reduced by mexiletine from 44.7 ± 5.1 to 25.4 ± 1.2 ml · hr−1. Both N-demethylated metabolites of theophylline were decreased by 60% by mexiletine, whose levels remained within its therapeutic range. Theophylline levels returned to pre-mexiletine values when this drug was discontinued. Mexiletine reduces theophylline clearance and increases its plasma concentration by inhibiting N-demethylation of theophylline. Plasma theophylline levels should be monitored when mexiletine is added. Clinical Pharmacology and Therapeutics (1991) 50, 299–307; doi:10.1038/clpt.1991.140" @default.
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- W2032390903 date "1991-09-01" @default.
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- W2032390903 title "Mexiletine effects on theophylline disposition" @default.
- W2032390903 doi "https://doi.org/10.1038/clpt.1991.140" @default.
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