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- W2032393049 abstract "The image of Streptococcus pneumoniae is split between the world of infectious diseases and the world of the science laboratory. In the eyes of medical practitioners and clinical microbiologists, this bacterium is a dangerous pathogen capable of causing potentially life-threatening community-acquired diseases. In the eyes of the microbiologist, S. pneumoniae is the microbe that has provided some of the most important insights into molecular biology. It was laboratory studies with S. pneumoniae that led to the identification of the first polysaccharide antigen, 1 Goebel W.F. Adams M.H. The immunological properties of the heterophile antigen and somatic polysaccharide of pneumococcus. J Exp Med. 1943; 77: 435-449 Crossref PubMed Scopus (18) Google Scholar the unique recombinational mechanism of genetic transformation, 2 Griffith F. The significance of pneumococcal types. J Hyg. 1928; 27: 113-159 Crossref PubMed Scopus (635) Google Scholar and identification of DNA as the genetic material 3 Avery O.T. MacLeod C.M. McCarty M. Studies on the chemical nature of the substance inducing transformation of pneumococcal types. Induction of transformation by a deoxyribonucleic acid fraction isolated from pneumococcus type III. J Exp Med. 1944; 79: 137-157 Crossref PubMed Scopus (1751) Google Scholar ; the first bacterial quorum-sensing polypeptide, a microbial hormone inducing and controlling the physiological state of competence, 4 Tomasz A. Control of the competent state in pneumococcus by a hormone-like cell product an example for a new type of regulatory mechanism in bacteria. Nature. 1965; 208: 155-159 Crossref PubMed Scopus (148) Google Scholar and the first bacterial autolysin, 5 Dubos R.J. Mechanism of the lysis of pneumococci by freezing and thawing, bile, and other agents. J Exp Med. 1937; 66: 101-112 Crossref PubMed Scopus (10) Google Scholar were also first identified in pneumococci." @default.
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- W2032393049 date "1999-07-01" @default.
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- W2032393049 title "New faces of an old pathogen: emergence and spread of multidrug-resistant Streptococcus pneumoniae" @default.
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- W2032393049 doi "https://doi.org/10.1016/s0002-9343(99)00107-2" @default.
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