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- W2032393744 abstract "Donor pretreatment with methylprednisolone (30 mg/kg) and/or glucagon (40 μg/kg) of adult Lewis rats before pancreas harvesting increased the insulin/amylase ratio prior to and after collagenase treatment. The respiratory control index and the number of islet cells were not significantly modified. The results of islet cell transplantation into the portal vein of isologous recipients varied according to the number of donors utilized. Similar results were obtained in animals transplanted with islet cells obtained from six donors whether they were pretreated or not. There were no significant differences in the glycemia post-transplantation when three donors were used for pretreated or control groups. However, animal survival was significantly (P < 0.005) improved in the donor pretreated groups. Donor pretreatment with methylprednisolone and/or glucagon appears to have some effect in stabilizing the release of insulin and amylase from islet cells. Further manipulations with these drugs could be even more helpful in improving islet cell function and survival." @default.
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- W2032393744 date "1960-01-01" @default.
- W2032393744 modified "2023-09-23" @default.
- W2032393744 title "The action of adenosine 3′, 5′-monophosphate on the incorporation of leucine into liver proteins" @default.
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- W2032393744 doi "https://doi.org/10.1016/0006-3002(60)90484-4" @default.
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