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- W2032404799 abstract "MANY CHILDREN with allergic rhinitis are denied the potential benefits of antihistamine therapy if they also have Their physicians have been taught that the antihistamines probably will exacerbate the asthma by a variety of mechanisms. ~ In the Physician's Desk Reference 2 (Medical Economics Company, Oradell, N J, 35th Edition, 1981) it is stated ... antihistamines should not be used to treat lower respiratory tract symptoms, including asthma. It is not stated, however, that they cannot be used for other allergic conditions if the asthma is under satisfactory control. Evidence accumulated in the past decade indicates that even this concern may not be clinically important. Several nonphenothiazine antihistamines do not adversely affect the peak flow rates of severely asthmatic children. 3 Oral administration of chlorpheniramine improves the peak flow rates and decreases the need for bronchodilators in children with mild asthma? Chlorpheniramine has been shown to improve pulmonary function and protect against histamine aerosol challenge? 7 Several studies have shown that ketotifen may be more effective than cromolyn sodium in the prevention of exercise-induced bronchospasm. 8 These studies have been criticized for a variety of reasons: they were of short duration, they were conducted in the artificial setting of a pulmonary function laboratory, or they looked only at measures of large airway function. We therefore sought to extend these studies under field conditions by examining the effect of antihistamine drugs on measurements of pulmonary function in asthmatic children with symptoms of seasonal allergic rhinitis." @default.
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- W2032404799 date "1982-09-01" @default.
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- W2032404799 title "Effect of antihistamine on pulmonary function of children with asthma" @default.
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- W2032404799 doi "https://doi.org/10.1016/s0022-3476(82)80087-5" @default.
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