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- W2032409964 endingPage "574" @default.
- W2032409964 startingPage "561" @default.
- W2032409964 abstract "Serotonin or 5-hydroxytryptamine (5-HT) is a neurotransmitter and hormone that contributes to the regulation of various physiological functions by its actions in the central nervous system (CNS) and in the respective organ systems. Peripheral 5-HT is predominantly produced by enterochromaffin (EC) cells of the gastrointestinal (GI) tract. These gut-resident cells produce much more 5-HT than all neuronal and other sources combined, establishing EC cells as the main source of this biogenic amine in the human body. Peripheral 5-HT is also a potent immune modulator and affects various immune cells through its receptors and via the recently identified process of serotonylation. Alterations in 5-HT signalling have been described in inflammatory conditions of the gut, such as inflammatory bowel disease. The association between 5-HT and inflammation, however, is not limited to the gut, as changes in 5-HT levels have also been reported in patients with allergic airway inflammation and rheumatoid arthritis. Based on searches for terms such as '5-HT', 'EC cell', 'immune cells' and 'inflammation' in pubmed.gov as well as by utilizing pertinent reviews, the current review aims to provide an update on the role of 5-HT in biological functions with a particular focus on immune activation and inflammation." @default.
- W2032409964 created "2016-06-24" @default.
- W2032409964 creator A5016221625 @default.
- W2032409964 creator A5089663827 @default.
- W2032409964 date "2014-12-11" @default.
- W2032409964 modified "2023-10-14" @default.
- W2032409964 title "The role of serotonin and its receptors in activation of immune responses and inflammation" @default.
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