Matches in SemOpenAlex for { <https://semopenalex.org/work/W2032418112> ?p ?o ?g. }
Showing items 1 to 58 of
58
with 100 items per page.
- W2032418112 abstract "Background: BNP is a cardiac peptide with vasodilatory, natriuretic and diuretic properties. Recent studies have suggested that its vasodilatory hypotensive properties may limit the renal actions of BNP, especially in patients with borderline low blood pressure. We have recently identified an alternatively spliced transcript for BNP (ASBNP) that includes a unique and distinct longer carboxyl-terminus consisting of 34 amino acids. Based upon preliminary studies, we generated a truncated form (ASBNP2.1) that contains the first 16 amino acids of the C-terminal of ASBNP. Method: We determined the cardiorenal and humoral actions of intravenous infusion of ASBNP2.1 at 2 pmol/kgmin, 10 pmol/kgmin and 100pmol/kgmin in 10 dogs with rapid ventricular pacing induced overt CHF (240 bpm for 10 days) (*p< 0.05). Results: IV infusion of ASBNP 2.1 increased aquaresis (from 0.19± 0.04 to 0.32± 0.07, 0.46± 0.11 and 0.39± 0.09ml/min*) without a significant change in urinary sodium excretion. Importantly, ASBNP 2.1 enhanced glomerular filtration rate (GFR), from 31± 4 to 47± 8, Titration of medications byHF nurses increases optimisation doses of key therapeutic agents" @default.
- W2032418112 created "2016-06-24" @default.
- W2032418112 creator A5014193048 @default.
- W2032418112 creator A5036359021 @default.
- W2032418112 creator A5062156561 @default.
- W2032418112 creator A5090322167 @default.
- W2032418112 date "2008-01-01" @default.
- W2032418112 modified "2023-10-16" @default.
- W2032418112 title "A novel aquaretic and GFR enhancing peptide without vascular vasodilatory actions in experimental CHF" @default.
- W2032418112 doi "https://doi.org/10.1016/j.hlc.2007.11.004" @default.
- W2032418112 hasPublicationYear "2008" @default.
- W2032418112 type Work @default.
- W2032418112 sameAs 2032418112 @default.
- W2032418112 citedByCount "0" @default.
- W2032418112 crossrefType "journal-article" @default.
- W2032418112 hasAuthorship W2032418112A5014193048 @default.
- W2032418112 hasAuthorship W2032418112A5036359021 @default.
- W2032418112 hasAuthorship W2032418112A5062156561 @default.
- W2032418112 hasAuthorship W2032418112A5090322167 @default.
- W2032418112 hasConcept C120770815 @default.
- W2032418112 hasConcept C126322002 @default.
- W2032418112 hasConcept C134018914 @default.
- W2032418112 hasConcept C159641895 @default.
- W2032418112 hasConcept C164705383 @default.
- W2032418112 hasConcept C2775915353 @default.
- W2032418112 hasConcept C2778198053 @default.
- W2032418112 hasConcept C2779918671 @default.
- W2032418112 hasConcept C71924100 @default.
- W2032418112 hasConcept C84393581 @default.
- W2032418112 hasConcept C98274493 @default.
- W2032418112 hasConceptScore W2032418112C120770815 @default.
- W2032418112 hasConceptScore W2032418112C126322002 @default.
- W2032418112 hasConceptScore W2032418112C134018914 @default.
- W2032418112 hasConceptScore W2032418112C159641895 @default.
- W2032418112 hasConceptScore W2032418112C164705383 @default.
- W2032418112 hasConceptScore W2032418112C2775915353 @default.
- W2032418112 hasConceptScore W2032418112C2778198053 @default.
- W2032418112 hasConceptScore W2032418112C2779918671 @default.
- W2032418112 hasConceptScore W2032418112C71924100 @default.
- W2032418112 hasConceptScore W2032418112C84393581 @default.
- W2032418112 hasConceptScore W2032418112C98274493 @default.
- W2032418112 hasLocation W20324181121 @default.
- W2032418112 hasOpenAccess W2032418112 @default.
- W2032418112 hasPrimaryLocation W20324181121 @default.
- W2032418112 hasRelatedWork W1992753622 @default.
- W2032418112 hasRelatedWork W2007199634 @default.
- W2032418112 hasRelatedWork W2011347913 @default.
- W2032418112 hasRelatedWork W2034133041 @default.
- W2032418112 hasRelatedWork W2087314277 @default.
- W2032418112 hasRelatedWork W2119592260 @default.
- W2032418112 hasRelatedWork W2304633692 @default.
- W2032418112 hasRelatedWork W2322900513 @default.
- W2032418112 hasRelatedWork W2399063111 @default.
- W2032418112 hasRelatedWork W2899084033 @default.
- W2032418112 isParatext "false" @default.
- W2032418112 isRetracted "false" @default.
- W2032418112 magId "2032418112" @default.
- W2032418112 workType "article" @default.