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• W2032461805 abstract "Purpose Disturbances in the regulation of retinal blood flow are a hallmark of vision threatening diseases. Retinal blood flow is controlled by autoregulation, which involves Ca2+ activity in a recently identified population of perivascular cells with pericyte characteristics (PVCs). The purpose of the study was to identify the sources of Ca2+ recruitment in these PVCs during stimulation of porcine retinal arterioles in vitro with PGE2 and PGF2a. Methods Porcine retinal arterioles with preserved perivascular retinal tissue were mounted in a confocal myograph, placed in a confocal microscope and loaded with Oregon Green. After addition of PGE2 (10-5 M) or PGF2a (10-5 M) arteriolar tone and fluorescence from PVCs were recorded simultaneously in the absence and in the presence of Ca2+ channel blockers (ryanodine, nifedipine, LOE908, CPA, 2-APB). Results PGE2 induced significant relaxation of preconstricted retinal arterioles and Ca2+ activity in PVCs. The percentage of active PVCs, and the number but not the amplitude of Ca2+ oscillations were significantly reduced by CPA and 2-APB, but not by ryanodine, nifedipine and LOE908. PGF2acaused arteriolar contraction and the percentage of active PVCs, the number and the amplitude of Ca2+ oscillations were significantly reduced by CPA and 2-APB. Conclusion Ca2+ activity in PVCs accompanies porcine retinal arterioles responses to PGE2 and PGF2aSarcoplasmic reticulum and inositol triphosphate receptors are important sources of this Ca2+ activity. The amplitude of Ca2+ oscillations seems to play a particular role in contraction of retinal arterioles." @default.
• W2032461805 created "2016-06-24" @default.
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• W2032461805 date "2014-08-20" @default.
• W2032461805 modified "2023-10-18" @default.
• W2032461805 title "PGE2 and PGF2a stimulation of porcine retinal arterioles in vitro is associated with Ca2+ activity in retinal perivascular cells" @default.
• W2032461805 doi "https://doi.org/10.1111/j.1755-3768.2014.4744.x" @default.
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