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• W2032482854 endingPage "2425" @default.
• W2032482854 startingPage "2419" @default.
• W2032482854 abstract "Two of the gamma-aminobutyric acid (GABA) receptors, GABAA and GABAC, are ligand-gated chloride channels expressed by neurons in the retina and throughout the central nervous system. The different subunit composition of these two classes of GABA receptor result in very different physiological and pharmacological properties. Although little is known at the molecular level as to the subunit composition of any native GABA receptor, it is thought that GABAC receptors are homomeric assemblies of rho-subunits. However, we found that the kinetic and pharmacological properties of homomeric receptors formed by each of the rho-subunits cloned from perch retina did not resemble those of the GABAC receptors on perch bipolar cells. Because both GABAA and GABAC receptors are present on retinal bipolar cells, we attempted to determine whether subunits of these two receptor classes are capable of interacting with each other. We report here that, when coexpressed in Xenopus oocytes, heteromeric (rho 1B gamma 2) receptors formed by coassembly of the rho 1B-subunit with the gamma 2-subunit of the GABAA receptor displayed response properties very similar to those obtained with current recordings from bipolar cells. In addition to being unresponsive to bicuculline and diazepam, the time-constant of deactivation, and the sensitivities to GABA, picrotoxin and zinc closely approximated the values obtained from the native GABAC receptors on bipolar cells. These results provide the first direct evidence of interaction between GABA rho and GABAA receptor subunits. It seems highly likely that coassembly of GABAA and rho-subunits contributes to the molecular organization of GABAC receptors in the retina and perhaps throughout the nervous system." @default.
• W2032482854 created "2016-06-24" @default.
• W2032482854 creator A5009861309 @default.
• W2032482854 creator A5020622627 @default.
• W2032482854 date "1999-12-07" @default.
• W2032482854 modified "2023-10-18" @default.
• W2032482854 title "Response kinetics and pharmacological properties of heteromeric receptors formed by coassembly of GABA rho- and gamma2-subunits" @default.
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• W2032482854 doi "https://doi.org/10.1098/rspb.1999.0941" @default.
• W2032482854 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/1690471" @default.
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• W2032482854 hasPublicationYear "1999" @default.
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