FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2032489735> ?p ?o ?g. }

• W2032489735 endingPage "304" @default.
• W2032489735 startingPage "299" @default.
• W2032489735 abstract "Eukaryotic translation initiation factor 4E (eIF4E) is the cap-binding protein that binds the 5' cap structure of cellular messenger RNAs (mRNAs). Despite the obligatory role of eIF4E in cap-dependent mRNA translation, how the translation activity of eIF4E is controlled remains largely undefined. Here, we report that mammalian eIF4E is regulated by SUMO1 (small ubiquitin-related modifier 1) conjugation. eIF4E sumoylation promotes the formation of the active eIF4F translation initiation complex and induces the translation of a subset of proteins that are essential for cell proliferation and preventing apoptosis. Furthermore, disruption of eIF4E sumoylation inhibits eIF4E-dependent protein translation and abrogates the oncogenic and antiapoptotic functions associated with eIF4E. These data indicate that sumoylation is a new fundamental regulatory mechanism of protein synthesis. Our findings suggest further that eIF4E sumoylation might be important in promoting human cancers." @default.
• W2032489735 created "2016-06-24" @default.
• W2032489735 creator A5013779298 @default.
• W2032489735 creator A5014916592 @default.
• W2032489735 creator A5018516855 @default.
• W2032489735 creator A5056350557 @default.
• W2032489735 creator A5071178162 @default.
• W2032489735 date "2010-03-12" @default.
• W2032489735 modified "2023-10-11" @default.
• W2032489735 title "Sumoylation of eIF4E activates mRNA translation" @default.
• W2032489735 cites W1555945582 @default.
• W2032489735 cites W1867818493 @default.
• W2032489735 cites W1964675052 @default.
• W2032489735 cites W1968919723 @default.
• W2032489735 cites W1974907782 @default.
• W2032489735 cites W1975059674 @default.
• W2032489735 cites W1997161800 @default.
• W2032489735 cites W1997806157 @default.
• W2032489735 cites W1999057135 @default.
• W2032489735 cites W2005056727 @default.
• W2032489735 cites W2013108773 @default.
• W2032489735 cites W2032319312 @default.
• W2032489735 cites W2063905858 @default.
• W2032489735 cites W2095208614 @default.
• W2032489735 cites W2096524557 @default.
• W2032489735 cites W2106162257 @default.
• W2032489735 cites W2112441454 @default.
• W2032489735 cites W2121212016 @default.
• W2032489735 cites W2129615992 @default.
• W2032489735 cites W2132519593 @default.
• W2032489735 cites W2137238711 @default.
• W2032489735 cites W2139424276 @default.
• W2032489735 cites W2148915086 @default.
• W2032489735 cites W2157497892 @default.
• W2032489735 cites W2163382569 @default.
• W2032489735 cites W95252060 @default.
• W2032489735 doi "https://doi.org/10.1038/embor.2010.18" @default.
• W2032489735 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2854592" @default.
• W2032489735 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/20224576" @default.
• W2032489735 hasPublicationYear "2010" @default.
• W2032489735 type Work @default.
• W2032489735 sameAs 2032489735 @default.
• W2032489735 citedByCount "40" @default.
• W2032489735 countsByYear W20324897352012 @default.
• W2032489735 countsByYear W20324897352013 @default.
• W2032489735 countsByYear W20324897352014 @default.
• W2032489735 countsByYear W20324897352015 @default.
• W2032489735 countsByYear W20324897352016 @default.
• W2032489735 countsByYear W20324897352017 @default.
• W2032489735 countsByYear W20324897352018 @default.
• W2032489735 countsByYear W20324897352020 @default.
• W2032489735 countsByYear W20324897352021 @default.
• W2032489735 countsByYear W20324897352022 @default.
• W2032489735 countsByYear W20324897352023 @default.
• W2032489735 crossrefType "journal-article" @default.
• W2032489735 hasAuthorship W2032489735A5013779298 @default.
• W2032489735 hasAuthorship W2032489735A5014916592 @default.
• W2032489735 hasAuthorship W2032489735A5018516855 @default.
• W2032489735 hasAuthorship W2032489735A5056350557 @default.
• W2032489735 hasAuthorship W2032489735A5071178162 @default.
• W2032489735 hasBestOaLocation W20324897352 @default.
• W2032489735 hasConcept C104317684 @default.
• W2032489735 hasConcept C105580179 @default.
• W2032489735 hasConcept C149364088 @default.
• W2032489735 hasConcept C153911025 @default.
• W2032489735 hasConcept C161295673 @default.
• W2032489735 hasConcept C171350616 @default.
• W2032489735 hasConcept C25602115 @default.
• W2032489735 hasConcept C33277056 @default.
• W2032489735 hasConcept C3675279 @default.
• W2032489735 hasConcept C4718897 @default.
• W2032489735 hasConcept C5122226 @default.
• W2032489735 hasConcept C54355233 @default.
• W2032489735 hasConcept C62493599 @default.
• W2032489735 hasConcept C86803240 @default.
• W2032489735 hasConcept C95444343 @default.
• W2032489735 hasConcept C97154109 @default.
• W2032489735 hasConceptScore W2032489735C104317684 @default.
• W2032489735 hasConceptScore W2032489735C105580179 @default.
• W2032489735 hasConceptScore W2032489735C149364088 @default.
• W2032489735 hasConceptScore W2032489735C153911025 @default.
• W2032489735 hasConceptScore W2032489735C161295673 @default.
• W2032489735 hasConceptScore W2032489735C171350616 @default.
• W2032489735 hasConceptScore W2032489735C25602115 @default.
• W2032489735 hasConceptScore W2032489735C33277056 @default.
• W2032489735 hasConceptScore W2032489735C3675279 @default.
• W2032489735 hasConceptScore W2032489735C4718897 @default.
• W2032489735 hasConceptScore W2032489735C5122226 @default.
• W2032489735 hasConceptScore W2032489735C54355233 @default.
• W2032489735 hasConceptScore W2032489735C62493599 @default.
• W2032489735 hasConceptScore W2032489735C86803240 @default.
• W2032489735 hasConceptScore W2032489735C95444343 @default.
• W2032489735 hasConceptScore W2032489735C97154109 @default.
• W2032489735 hasIssue "4" @default.
• W2032489735 hasLocation W20324897351 @default.
• W2032489735 hasLocation W20324897352 @default.
• W2032489735 hasLocation W20324897353 @default.
• W2032489735 hasLocation W20324897354 @default.

• next