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- W20325017 abstract "Micromolar concentrations of cis-fatty acid synergistically activate type III protein kinase C with diacylglycerol. This synergistic effect occurs at low concentrations of cis-fatty acid and diacylglycerol, and it is capable of inducing almost full activation of this protein kinase C subtype at a physiologically relevant Ca2+ concentration (2 microM). The synergistic activation mode can be observed even in the absence of Ca2+, but micromolar Ca2+ significantly enhances the type III protein kinase C activation. cis-Fatty acid also augments the diacylglycerol-induced activation of other subtypes (type I and II), although the effect is smaller than that observed in type III. Neither the diacylglycerol- nor the cis-fatty acid-dependent mode of activation can fully activate any of these subtypes at a physiological concentration of Ca2+ (2 microM). Our results suggest that the generation of three second messengers, i.e. the increase in intracellular Ca2+ concentration and the generation of both cis-fatty acid and diacylglycerol in the cell, may be necessary signals for protein kinase C activation, particularly for type III protein kinase C." @default.
- W20325017 created "2016-06-24" @default.
- W20325017 creator A5053032272 @default.
- W20325017 creator A5058558025 @default.
- W20325017 date "1992-02-15" @default.
- W20325017 modified "2023-09-23" @default.
- W20325017 title "Synergistic activation of type III protein kinase C by <i>cis</i>-fatty acid and diacylglycerol" @default.
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- W20325017 doi "https://doi.org/10.1042/bj2820033" @default.
- W20325017 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/1130886" @default.
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