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- W2032518843 abstract "Can we design and produce novel proteins with desired structures and functions using amino acid sequences not found in nature? The design principles, abstracted from observation of natural proteins, are simplest for α-helical bundles, more complicated for β-sheet or mixed structures, and most subtle for the design of catalytic function. The simplest designs have been the most successful so far, but we have yet to encounter an experimentally determined three-dimensional structure for any de novo designed protein that folded as expected. The field is still in its infancy, but its ultimate potential for applications is enormous." @default.
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- W2032518843 date "1991-08-01" @default.
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- W2032518843 title "De novo design of proteins" @default.
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