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• W2032537344 abstract "Abstract • Several studies have shown that newborn pigs are unable to maintain normal blood sugar when fasted immediately after birth. Among the reasons postulated were a defect or late maturation in a key regulatory enzyme of gluconeogenesis. Recently, glucose-6-phosphate, fructose diphosphate and phosphopyruvate carboxylase activities were shown to be low in fetal tissue and to increase within 48 h to levels observed in older normal glycemic animals. The present study was undertaken to determine if an enzymatic defect existed in pyruvate carboxylase and to determine the rates of gluconeogenesis in pig liver with respect to development and maturation. • The hepatic enzyme pyruvate carboxylase was found to be low in 1-day-old pigs and to increase 3–4 fold within 4 days. In addition, fructokinase was found to be completely absent in newborn liver and to remain low in animals until 10 days of age. The conversion rate of fructose to glucose in liver slices was found to follow the enzymatic developmental pattern. • The conversion of precursor substrates such as lactate, pyruvate, glycerol and dihydroxyacetone to glucose did not occur in 1-day-old, 24-h-fasted piglets. A significant increase in hepatic gluconeogenesis occurred 2–6 days postnatally and a further increase was found at 10–16 days of life. • The present study demonstrates that the newborn pig liver has a decreased gluconeogenic capacity in comparison to older pig liver and that the low rate may help to explain why the neonatal pig has difficulty in maintaining normal blood glucose when fasted immediately after birth. The relatively low rate of lactate and pyruvate conversion to glucose for 1–3 days may possible be enzyme limited although both pyruvate carboxylase and phosphopyruvate carboxylase are elevated by the 3rd day of life to levels found in older normal glycemic fasted pigs." @default.
• W2032537344 created "2016-06-24" @default.
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• W2032537344 date "1971-11-01" @default.
• W2032537344 modified "2023-09-25" @default.
• W2032537344 title "Development of gluconeogenesis in pig liver slices" @default.
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• W2032537344 doi "https://doi.org/10.1016/0304-4165(71)90007-9" @default.
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