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- W2032538261 endingPage "127" @default.
- W2032538261 startingPage "114" @default.
- W2032538261 abstract "Summary: Group B streptococcus (GBS) is part of the normal genital and gastrointestinal flora in healthy humans. However, GBS is a major cause of sepsis and meningitis in newborn infants in the Western world and an important pathogen in many developing countries. The dissection of the host response to GBS may increase the general understanding of innate immunity in sepsis, because newborn infants lack a sufficient adaptive response. Inflammatory signal induction in macrophages by GBS seems largely preserved in newborn infants, as shown both in vitro and in vivo . The engagement of Toll‐like receptor 2 (TLR2) by lipoproteins and a myeloid differentiation factor 88 (MyD88)‐dependent pathway induced by GBS cell wall are both important in this context. TLR2 activation of microglia by GBS induces neuronal damage, which might account for the high morbidity of GBS meningitis. At the same time, TLR2 mediates activation‐induced cell death (AICD), a process involved in the containment of inflammation. In newborn infants, AICD and anti‐bacterial polymorphonuclear leukocyte activity appears to be compromised. Accordingly, neonatal aberrations in the pathogen‐specific negative control of inflammatory signaling are likely to contribute to excessive inflammation and neurological sequelae in GBS sepsis and meningitis." @default.
- W2032538261 created "2016-06-24" @default.
- W2032538261 creator A5009943526 @default.
- W2032538261 creator A5021732665 @default.
- W2032538261 date "2008-09-19" @default.
- W2032538261 modified "2023-10-16" @default.
- W2032538261 title "Induction and termination of inflammatory signaling in group B streptococcal sepsis" @default.
- W2032538261 cites W10482017 @default.
- W2032538261 cites W1481505452 @default.
- W2032538261 cites W1481676924 @default.
- W2032538261 cites W1485348851 @default.
- W2032538261 cites W1497550398 @default.
- W2032538261 cites W1501181174 @default.
- W2032538261 cites W1508769591 @default.
- W2032538261 cites W1510436989 @default.
- W2032538261 cites W1521822265 @default.
- W2032538261 cites W1524835356 @default.
- W2032538261 cites W1525024972 @default.
- W2032538261 cites W1534699340 @default.
- W2032538261 cites W1538895700 @default.
- W2032538261 cites W1576071600 @default.
- W2032538261 cites W1576773659 @default.
- W2032538261 cites W1579217047 @default.
- W2032538261 cites W1584454203 @default.
- W2032538261 cites W1599185640 @default.
- W2032538261 cites W1671427082 @default.
- W2032538261 cites W1740130847 @default.
- W2032538261 cites W1869217923 @default.
- W2032538261 cites W1889825709 @default.
- W2032538261 cites W1917516267 @default.
- W2032538261 cites W1920180399 @default.
- W2032538261 cites W1941687931 @default.
- W2032538261 cites W1941961496 @default.
- W2032538261 cites W1957173764 @default.
- W2032538261 cites W1962480557 @default.
- W2032538261 cites W1963692246 @default.
- W2032538261 cites W1964627860 @default.
- W2032538261 cites W1969202621 @default.
- W2032538261 cites W1969913081 @default.
- W2032538261 cites W1969941746 @default.
- W2032538261 cites W1971929349 @default.
- W2032538261 cites W1972941561 @default.
- W2032538261 cites W1974247054 @default.
- W2032538261 cites W1976467135 @default.
- W2032538261 cites W1976756739 @default.
- W2032538261 cites W1977905350 @default.
- W2032538261 cites W1978633178 @default.
- W2032538261 cites W1980547319 @default.
- W2032538261 cites W1982185661 @default.
- W2032538261 cites W1982204342 @default.
- W2032538261 cites W1982713513 @default.
- W2032538261 cites W1989234621 @default.
- W2032538261 cites W1989548713 @default.
- W2032538261 cites W1991049513 @default.
- W2032538261 cites W1991526236 @default.
- W2032538261 cites W1992841021 @default.
- W2032538261 cites W1993832002 @default.
- W2032538261 cites W1994985348 @default.
- W2032538261 cites W1995744610 @default.
- W2032538261 cites W1998435868 @default.
- W2032538261 cites W2001883479 @default.
- W2032538261 cites W2003590292 @default.
- W2032538261 cites W2003654668 @default.
- W2032538261 cites W2003816035 @default.
- W2032538261 cites W2004536682 @default.
- W2032538261 cites W2005047699 @default.
- W2032538261 cites W2005463271 @default.
- W2032538261 cites W2007262051 @default.
- W2032538261 cites W2008152503 @default.
- W2032538261 cites W2008838298 @default.
- W2032538261 cites W2009185090 @default.
- W2032538261 cites W2010662462 @default.
- W2032538261 cites W2011290533 @default.
- W2032538261 cites W2013917952 @default.
- W2032538261 cites W2014012364 @default.
- W2032538261 cites W2014353622 @default.
- W2032538261 cites W2015831421 @default.
- W2032538261 cites W2017883909 @default.
- W2032538261 cites W2019929680 @default.
- W2032538261 cites W2023509911 @default.
- W2032538261 cites W2025134285 @default.
- W2032538261 cites W2026568037 @default.
- W2032538261 cites W2028707861 @default.
- W2032538261 cites W2031578421 @default.
- W2032538261 cites W2031737515 @default.
- W2032538261 cites W2034763496 @default.
- W2032538261 cites W2037870356 @default.
- W2032538261 cites W2038143978 @default.
- W2032538261 cites W2038787037 @default.
- W2032538261 cites W2039348809 @default.
- W2032538261 cites W2041308303 @default.
- W2032538261 cites W2042482956 @default.
- W2032538261 cites W2043801813 @default.
- W2032538261 cites W2043823247 @default.
- W2032538261 cites W2045948232 @default.
- W2032538261 cites W2046310813 @default.
- W2032538261 cites W2047730062 @default.
- W2032538261 cites W2053239039 @default.