Matches in SemOpenAlex for { <https://semopenalex.org/work/W2032562007> ?p ?o ?g. }
- W2032562007 abstract "In the search for therapeutic modifiers, frontotemporal dementia (FTD) has traditionally been overshadowed by other conditions such as Alzheimer’s disease. A clinically and pathologically diverse condition, FTD has been galvanized by a number of recent discoveries such as novel genetic variants in familial and sporadic forms of disease and the identification of TAR DNA binding protein of 43kDa (TDP-43) as the defining constituent of inclusions in more than half of cases. In combination with an ever-expanding knowledge of the function and dysfunction of tau - a protein which is pathologically aggregated in the majority of the remaining cases - there exists a greater understanding of FTD than ever before. These advances may indicate potential approaches for the development of hypothetical therapeutics, but FTD remains highly complex and the roles of tau and TDP-43 in neurodegeneration are still wholly unclear. Here the challenges facing potential therapeutic strategies are discussed, which include sufficiently accurate disease diagnosis and sophisticated technology to deliver effective therapies." @default.
- W2032562007 created "2016-06-24" @default.
- W2032562007 creator A5001609822 @default.
- W2032562007 creator A5047859535 @default.
- W2032562007 date "2014-08-19" @default.
- W2032562007 modified "2023-10-17" @default.
- W2032562007 title "Therapeutic and diagnostic challenges for frontotemporal dementia" @default.
- W2032562007 cites W104689190 @default.
- W2032562007 cites W122799512 @default.
- W2032562007 cites W143532300 @default.
- W2032562007 cites W1509571186 @default.
- W2032562007 cites W150987474 @default.
- W2032562007 cites W1511517753 @default.
- W2032562007 cites W1513401887 @default.
- W2032562007 cites W1538925586 @default.
- W2032562007 cites W1562314847 @default.
- W2032562007 cites W1578113876 @default.
- W2032562007 cites W1841575052 @default.
- W2032562007 cites W1964242395 @default.
- W2032562007 cites W1964347491 @default.
- W2032562007 cites W1965497520 @default.
- W2032562007 cites W1966682365 @default.
- W2032562007 cites W1967577586 @default.
- W2032562007 cites W1969979382 @default.
- W2032562007 cites W1970298138 @default.
- W2032562007 cites W1971165215 @default.
- W2032562007 cites W1974298458 @default.
- W2032562007 cites W1974607943 @default.
- W2032562007 cites W1974832498 @default.
- W2032562007 cites W1974961961 @default.
- W2032562007 cites W1978122964 @default.
- W2032562007 cites W1979000028 @default.
- W2032562007 cites W1979315191 @default.
- W2032562007 cites W1983014877 @default.
- W2032562007 cites W1983523416 @default.
- W2032562007 cites W1984145170 @default.
- W2032562007 cites W1984496263 @default.
- W2032562007 cites W1984538960 @default.
- W2032562007 cites W1984557585 @default.
- W2032562007 cites W1985053970 @default.
- W2032562007 cites W1985171431 @default.
- W2032562007 cites W1986117556 @default.
- W2032562007 cites W1987060533 @default.
- W2032562007 cites W1987618579 @default.
- W2032562007 cites W1988332799 @default.
- W2032562007 cites W1988650085 @default.
- W2032562007 cites W1990986671 @default.
- W2032562007 cites W1994089264 @default.
- W2032562007 cites W1994336523 @default.
- W2032562007 cites W1995139137 @default.
- W2032562007 cites W1995276702 @default.
- W2032562007 cites W1998212202 @default.
- W2032562007 cites W2000158949 @default.
- W2032562007 cites W2001443225 @default.
- W2032562007 cites W2002093269 @default.
- W2032562007 cites W2002662877 @default.
- W2032562007 cites W2005731595 @default.
- W2032562007 cites W2006622298 @default.
- W2032562007 cites W2006717582 @default.
- W2032562007 cites W2008377380 @default.
- W2032562007 cites W2008675281 @default.
- W2032562007 cites W2009870816 @default.
- W2032562007 cites W2011396520 @default.
- W2032562007 cites W2012781495 @default.
- W2032562007 cites W2014635801 @default.
- W2032562007 cites W2015074014 @default.
- W2032562007 cites W2016330834 @default.
- W2032562007 cites W2016758992 @default.
- W2032562007 cites W2017321290 @default.
- W2032562007 cites W2018911077 @default.
- W2032562007 cites W2018983416 @default.
- W2032562007 cites W2020159880 @default.
- W2032562007 cites W2020697171 @default.
- W2032562007 cites W2020719670 @default.
- W2032562007 cites W2022329592 @default.
- W2032562007 cites W2024163155 @default.
- W2032562007 cites W2025067765 @default.
- W2032562007 cites W2025452062 @default.
- W2032562007 cites W2027420858 @default.
- W2032562007 cites W2027460468 @default.
- W2032562007 cites W2028611597 @default.
- W2032562007 cites W2031923285 @default.
- W2032562007 cites W2032404852 @default.
- W2032562007 cites W2034234226 @default.
- W2032562007 cites W2036878135 @default.
- W2032562007 cites W2037053607 @default.
- W2032562007 cites W2040612189 @default.
- W2032562007 cites W2040639372 @default.
- W2032562007 cites W2041451000 @default.
- W2032562007 cites W2042213574 @default.
- W2032562007 cites W2044676388 @default.
- W2032562007 cites W2045311514 @default.
- W2032562007 cites W2045602910 @default.
- W2032562007 cites W2045921574 @default.
- W2032562007 cites W2047031330 @default.
- W2032562007 cites W2048560678 @default.
- W2032562007 cites W2049971831 @default.
- W2032562007 cites W2050328571 @default.
- W2032562007 cites W2050644696 @default.
- W2032562007 cites W2054068057 @default.