FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2032576685> ?p ?o ?g. }

• W2032576685 endingPage "86" @default.
• W2032576685 startingPage "76" @default.
• W2032576685 abstract "The lesion of the vestibular end organ evokes static and dynamic symptoms, which spontaneously regress during a complex process known as ‘vestibular compensation’. Vestibular compensation is age-dependent and involves several transmitter-identified pathways in the central nervous system. In this paper we studied the time course of vestibular compensation in adult (3 months) and old (24 months) rats and correlated behavioral recovery with modifications of glutamic acid decarboxylase (GAD) mRNA expression and benzodiazepine receptor density in different brain areas. Compensation in adult rats was complete 28 days after hemilabyrinthectomy, whereas old rats still showed significant behavioral impairment. A higher GABAergic tone was found in old rats, as indicated by higher benzodiazepine receptor density in lateral vestibular nucleus and higher mRNA level for glutamic acid decarboxylase in cerebral cortex and medial vestibular nucleus. In adult, compensated rats, benzodiazepine receptor density in the vestibular nuclei was normal 28 days after lesion, whereas GAD mRNA level was higher in anterior cingulate cortex, only. On the contrary, these parameters were still altered in anterior cingulate and somatosensory cortex, basal ganglia, vestibular nuclei and cerebellum in old rats 28 days after vestibular lesion. We also evaluated the effect of the ergoline derivative nicergoline on behavioral and neurochemical correlates of vestibular compensation in old rats. Nicergoline treatment attenuated the severity of oculomotor and postural symptoms after vestibular lesion and reversed most of these age- and lesion-induced alterations in GAD mRNA expression. Thus, lesion-related alterations of the GABAergic transmission and behavioral profile after vestibular lesion are age-dependent." @default.
• W2032576685 created "2016-06-24" @default.
• W2032576685 creator A5023384307 @default.
• W2032576685 creator A5029964724 @default.
• W2032576685 creator A5042003751 @default.
• W2032576685 creator A5044044440 @default.
• W2032576685 creator A5058327038 @default.
• W2032576685 creator A5074975609 @default.
• W2032576685 date "2002-03-01" @default.
• W2032576685 modified "2023-10-07" @default.
• W2032576685 title "Plasticity of GABA(a) system during ageing: focus on vestibular compensation and possible pharmacological intervention" @default.
• W2032576685 cites W1775681420 @default.
• W2032576685 cites W1967784117 @default.
• W2032576685 cites W1968603940 @default.
• W2032576685 cites W1973266603 @default.
• W2032576685 cites W1974466946 @default.
• W2032576685 cites W1974821373 @default.
• W2032576685 cites W1975443710 @default.
• W2032576685 cites W1976946227 @default.
• W2032576685 cites W1977725656 @default.
• W2032576685 cites W1977949487 @default.
• W2032576685 cites W1979374481 @default.
• W2032576685 cites W1979605483 @default.
• W2032576685 cites W1981943483 @default.
• W2032576685 cites W1983721374 @default.
• W2032576685 cites W1987691352 @default.
• W2032576685 cites W1992395161 @default.
• W2032576685 cites W1992397770 @default.
• W2032576685 cites W1993974374 @default.
• W2032576685 cites W1994134014 @default.
• W2032576685 cites W2000168242 @default.
• W2032576685 cites W2004674977 @default.
• W2032576685 cites W2007698124 @default.
• W2032576685 cites W2009119528 @default.
• W2032576685 cites W2010668079 @default.
• W2032576685 cites W2010729374 @default.
• W2032576685 cites W2015278483 @default.
• W2032576685 cites W2020154808 @default.
• W2032576685 cites W2020416524 @default.
• W2032576685 cites W2022608896 @default.
• W2032576685 cites W2028517578 @default.
• W2032576685 cites W2029650881 @default.
• W2032576685 cites W2033535736 @default.
• W2032576685 cites W2036714953 @default.
• W2032576685 cites W2043008938 @default.
• W2032576685 cites W2045372221 @default.
• W2032576685 cites W2052050547 @default.
• W2032576685 cites W2052261815 @default.
• W2032576685 cites W2053692618 @default.
• W2032576685 cites W2054194062 @default.
• W2032576685 cites W2057905921 @default.
• W2032576685 cites W2063170050 @default.
• W2032576685 cites W2070379477 @default.
• W2032576685 cites W2075316492 @default.
• W2032576685 cites W2081296585 @default.
• W2032576685 cites W2086057482 @default.
• W2032576685 cites W2089816202 @default.
• W2032576685 cites W2090287644 @default.
• W2032576685 cites W2093902197 @default.
• W2032576685 cites W2094147244 @default.
• W2032576685 cites W2094317402 @default.
• W2032576685 cites W2101928577 @default.
• W2032576685 cites W2108611459 @default.
• W2032576685 cites W2111885223 @default.
• W2032576685 cites W2141497247 @default.
• W2032576685 cites W2147261581 @default.
• W2032576685 cites W2166496419 @default.
• W2032576685 cites W2203549116 @default.
• W2032576685 cites W2323367758 @default.
• W2032576685 cites W4229528864 @default.
• W2032576685 cites W4245291742 @default.
• W2032576685 cites W4251009677 @default.
• W2032576685 doi "https://doi.org/10.1016/s0006-8993(01)03381-9" @default.
• W2032576685 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/11852033" @default.
• W2032576685 hasPublicationYear "2002" @default.
• W2032576685 type Work @default.
• W2032576685 sameAs 2032576685 @default.
• W2032576685 citedByCount "36" @default.
• W2032576685 countsByYear W20325766852013 @default.
• W2032576685 countsByYear W20325766852015 @default.
• W2032576685 countsByYear W20325766852016 @default.
• W2032576685 countsByYear W20325766852017 @default.
• W2032576685 countsByYear W20325766852019 @default.
• W2032576685 countsByYear W20325766852020 @default.
• W2032576685 countsByYear W20325766852021 @default.
• W2032576685 countsByYear W20325766852022 @default.
• W2032576685 countsByYear W20325766852023 @default.
• W2032576685 crossrefType "journal-article" @default.
• W2032576685 hasAuthorship W2032576685A5023384307 @default.
• W2032576685 hasAuthorship W2032576685A5029964724 @default.
• W2032576685 hasAuthorship W2032576685A5042003751 @default.
• W2032576685 hasAuthorship W2032576685A5044044440 @default.
• W2032576685 hasAuthorship W2032576685A5058327038 @default.
• W2032576685 hasAuthorship W2032576685A5074975609 @default.
• W2032576685 hasConcept C126322002 @default.
• W2032576685 hasConcept C134018914 @default.
• W2032576685 hasConcept C142724271 @default.
• W2032576685 hasConcept C15744967 @default.

• next