FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2032578306> ?p ?o ?g. }

• W2032578306 endingPage "19340" @default.
• W2032578306 startingPage "19335" @default.
• W2032578306 abstract "Unlike the dominant role of one class II invariant chain peptide (CLIP) in blocking MHC class II, comparative lipidomics analysis shows that human cluster of differentiation (CD) proteins CD1a, CD1b, CD1c, and CD1d bind lipids corresponding to hundreds of diverse accurate mass retention time values. Although most ions were observed in association with several CD1 proteins, ligands binding selectively to one CD1 isoform allowed the study of how differing antigen-binding grooves influence lipid capture. Although the CD1b groove is distinguished by its unusually large volume (2,200 Å 3 ) and the T′ tunnel, the average mass of compounds eluted from CD1b was similar to that of lipids from CD1 proteins with smaller grooves. Elution of small ligands from the large CD1b groove might be explained if two small lipids bind simultaneously in the groove. Crystal structures indicate that all CD1 proteins can capture one antigen with its hydrophilic head group exposed for T-cell recognition, but CD1b structures show scaffold lipids seated below the antigen. We found that ligands selectively associated with CD1b lacked the hydrophilic head group that is generally needed for antigen recognition but interferes with scaffold function. Furthermore, we identified the scaffolds as deoxyceramides and diacylglycerols and directly demonstrate a function in augmenting presentation of a small glycolipid antigen to T cells. Thus, unlike MHC class II, CD1 proteins capture highly diverse ligands in the secretory pathway. CD1b has a mechanism for presenting either two small or one large lipid, allowing presentation of antigens with an unusually broad range of chain lengths." @default.
• W2032578306 created "2016-06-24" @default.
• W2032578306 creator A5013442775 @default.
• W2032578306 creator A5017527950 @default.
• W2032578306 creator A5042696398 @default.
• W2032578306 creator A5046655671 @default.
• W2032578306 creator A5047325414 @default.
• W2032578306 creator A5049766003 @default.
• W2032578306 creator A5049956452 @default.
• W2032578306 creator A5055116150 @default.
• W2032578306 creator A5075953446 @default.
• W2032578306 date "2011-11-15" @default.
• W2032578306 modified "2023-10-16" @default.
• W2032578306 title "Discovery of deoxyceramides and diacylglycerols as CD1b scaffold lipids among diverse groove-blocking lipids of the human CD1 system" @default.
• W2032578306 cites W1522913832 @default.
• W2032578306 cites W1536006864 @default.
• W2032578306 cites W1653420790 @default.
• W2032578306 cites W1813398788 @default.
• W2032578306 cites W1963584953 @default.
• W2032578306 cites W1966344619 @default.
• W2032578306 cites W1969975683 @default.
• W2032578306 cites W1974241771 @default.
• W2032578306 cites W1987275221 @default.
• W2032578306 cites W1989626793 @default.
• W2032578306 cites W1991320900 @default.
• W2032578306 cites W2004060523 @default.
• W2032578306 cites W2013857975 @default.
• W2032578306 cites W2028789155 @default.
• W2032578306 cites W2030210503 @default.
• W2032578306 cites W2036130970 @default.
• W2032578306 cites W2045408415 @default.
• W2032578306 cites W2053088462 @default.
• W2032578306 cites W2056848105 @default.
• W2032578306 cites W2060314550 @default.
• W2032578306 cites W2061153820 @default.
• W2032578306 cites W2063841466 @default.
• W2032578306 cites W2064794064 @default.
• W2032578306 cites W2080442125 @default.
• W2032578306 cites W2085116778 @default.
• W2032578306 cites W2085831528 @default.
• W2032578306 cites W2103940234 @default.
• W2032578306 cites W2105433002 @default.
• W2032578306 cites W2120832265 @default.
• W2032578306 cites W2151271024 @default.
• W2032578306 cites W2160617431 @default.
• W2032578306 cites W2163164309 @default.
• W2032578306 cites W2169339649 @default.
• W2032578306 doi "https://doi.org/10.1073/pnas.1112969108" @default.
• W2032578306 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3228429" @default.
• W2032578306 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/22087000" @default.
• W2032578306 hasPublicationYear "2011" @default.
• W2032578306 type Work @default.
• W2032578306 sameAs 2032578306 @default.
• W2032578306 citedByCount "65" @default.
• W2032578306 countsByYear W20325783062012 @default.
• W2032578306 countsByYear W20325783062013 @default.
• W2032578306 countsByYear W20325783062014 @default.
• W2032578306 countsByYear W20325783062015 @default.
• W2032578306 countsByYear W20325783062016 @default.
• W2032578306 countsByYear W20325783062017 @default.
• W2032578306 countsByYear W20325783062018 @default.
• W2032578306 countsByYear W20325783062019 @default.
• W2032578306 countsByYear W20325783062020 @default.
• W2032578306 countsByYear W20325783062021 @default.
• W2032578306 countsByYear W20325783062022 @default.
• W2032578306 countsByYear W20325783062023 @default.
• W2032578306 crossrefType "journal-article" @default.
• W2032578306 hasAuthorship W2032578306A5013442775 @default.
• W2032578306 hasAuthorship W2032578306A5017527950 @default.
• W2032578306 hasAuthorship W2032578306A5042696398 @default.
• W2032578306 hasAuthorship W2032578306A5046655671 @default.
• W2032578306 hasAuthorship W2032578306A5047325414 @default.
• W2032578306 hasAuthorship W2032578306A5049766003 @default.
• W2032578306 hasAuthorship W2032578306A5049956452 @default.
• W2032578306 hasAuthorship W2032578306A5055116150 @default.
• W2032578306 hasAuthorship W2032578306A5075953446 @default.
• W2032578306 hasBestOaLocation W20325783061 @default.
• W2032578306 hasConcept C139563560 @default.
• W2032578306 hasConcept C147483822 @default.
• W2032578306 hasConcept C154317977 @default.
• W2032578306 hasConcept C170627219 @default.
• W2032578306 hasConcept C185592680 @default.
• W2032578306 hasConcept C202751555 @default.
• W2032578306 hasConcept C207936829 @default.
• W2032578306 hasConcept C22222904 @default.
• W2032578306 hasConcept C2778607024 @default.
• W2032578306 hasConcept C37386791 @default.
• W2032578306 hasConcept C54355233 @default.
• W2032578306 hasConcept C55493867 @default.
• W2032578306 hasConcept C67662055 @default.
• W2032578306 hasConcept C83464605 @default.
• W2032578306 hasConcept C86803240 @default.
• W2032578306 hasConcept C95444343 @default.
• W2032578306 hasConceptScore W2032578306C139563560 @default.
• W2032578306 hasConceptScore W2032578306C147483822 @default.
• W2032578306 hasConceptScore W2032578306C154317977 @default.
• W2032578306 hasConceptScore W2032578306C170627219 @default.
• W2032578306 hasConceptScore W2032578306C185592680 @default.

• next